| Tag | Content |
|---|
| CPLM ID | CPLM-008493 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA-directed RNA polymerases I and III subunit RPAC1 |
Protein Synonyms/Alias | DNA-directed RNA polymerase I subunit C; RNA polymerases I and III subunit AC1; AC40; DNA-directed RNA polymerases I and III 40 kDa polypeptide; RPA40; RPC40 |
Gene Name | Polr1c |
Gene Synonyms/Alias | Rpo1-1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 224 | GIGKDHAKFSPVATA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Complete proteome; DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 346 AA |
Protein Sequence | MAAAQAVEEM RTRVVLGEFG VRNVHTTDFP GNYAGYDDAW DQNRFEKNFR VDVVQMDEDT 60
LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPILADPR 120
LFEYRNQGEE EGTEIDTLQF RLQVRCTRNP NAAKDSSDPN ELYVNHKVYT RHMTWVPLGN 180
QADVFPEGTI RPVHDDILIA QLRPGQEIDL MMHCVKGIGK DHAKFSPVAT ASYRLLPAIT 240
LLEPVEGEAA EELSQCFSPG VIEVEEVQGK KVARVANARL DTFSREIFRH EKLKKAVRLA 300
RVRDHYIFSV ESTGVLPPDV LVSEAIKILM GKCRRFLDEL DAVEMD 346 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003677; F:DNA binding; IEA:InterPro. GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |