| Tag | Content |
|---|
| CPLM ID | CPLM-008978 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cadherin-4 |
Protein Synonyms/Alias | Retinal cadherin; R-CAD; R-cadherin |
Gene Name | CDH4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 66 | FSSCVGTKGTQYETN | ubiquitination | [1] | | 132 | SSPHSGHKPQKGKKV | ubiquitination | [1] | | 149 | LDPSPPPKDTLLPWP | ubiquitination | [1] | | 546 | QQAVRYSKLSDPASW | ubiquitination | [1] | | 660 | FVPAAVRKNWTITRL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. |
Sequence Annotation | DOMAIN 170 277 Cadherin 1.
DOMAIN 278 392 Cadherin 2.
DOMAIN 393 507 Cadherin 3.
DOMAIN 508 613 Cadherin 4.
DOMAIN 614 724 Cadherin 5.
CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).
CARBOHYD 412 412 N-linked (GlcNAc...) (Potential).
CARBOHYD 557 557 N-linked (GlcNAc...) (Potential).
CARBOHYD 632 632 N-linked (GlcNAc...) (Potential).
CARBOHYD 661 661 N-linked (GlcNAc...) (Potential).
CARBOHYD 702 702 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 916 AA |
Protein Sequence | MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE GEKLLQVKFS 60
SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF TVTAWDSQTA EKWDAVVRLL 120
VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD TLLPWPQHQN ANGLRRRKRD WVIPPINVPE 180
NSRGPFPQQL VRIRSDKDND IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH 240
ASYHLRAHAV DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT 300
ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE KVQQYTVIVQ 360
ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE VPENRVETVV ANLTVMDRDQ 420
PHSPNWNAVY RIISGDPSGH FSVRTDPVTN EGMVTVVKAV DYELNRAFML TVMVSNQAPL 480
ASGIQMSFQS TAGVTISIMD INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ 540
AVRYSKLSDP ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT 600
LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE LPFVPAAVRK 660
NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL SNTSIIKVKV CPCDDNGDCT 720
TIGAVAAAGL GTGAIVAILI CILILLTMVL LFVMWMKRRE KERHTKQLLI DPEDDVRDNI 780
LKYDEEGGGE EDQDYDLSQL QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG 840
DIGDFINEGL RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG 900
PRFKKLADMY GGGEED 916 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IEA:Compara. GO:0005886; C:plasma membrane; IDA:HPA. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0034332; P:adherens junction organization; TAS:Reactome. GO:0007411; P:axon guidance; IEA:Compara. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0034329; P:cell junction assembly; TAS:Reactome. GO:0007157; P:heterophilic cell-cell adhesion; IEA:Compara. GO:0007156; P:homophilic cell adhesion; IEA:Compara. GO:0045773; P:positive regulation of axon extension; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |