CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Unconventional myosin-Va 
Protein Synonyms/Alias
  
Gene Name
 MYO5A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
222DNSSRFGKYIEIGFDacetylation[1]
979QLSEEEAKVATGRVLubiquitination[2]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1880 AA 
Protein Sequence
MKSSSLETMF ARVWIPDPEE VWKSAELLKD YKPGDKVLLL HLEEGKDLEY HLDPKTKELP 60
HLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFIDSKLIY TYCGIVLVAI NPYEQLPIYG 120
EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRYF 180
ATVSGSASEA NVEEKVLASN PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR 240
TYLLEKSRVV FQAEEERNYH IFYQLCASAK LPEFKMLRLG NADNFNYTKQ GGSPVIEGVD 300
DAKEMAHTRQ ACTLLGISES HQMGIFRILA GILHLGNVGF TSRDADSCTI PPKHEPLCIF 360
CELMGVDYEE MCHWLCHRKL ATATETYIKP ISKLQATNAR DALAKHIYAK LFNWIVDNVN 420
QALHSAVKQH SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNMHVF KLEQEEYMKE 480
QIPWTLIDFY DNQPCINLIE SKLGILDLLD EECKMPKGTD DTWAQKLYNT HLNKCALFEK 540
PRLSNKAFII QHFADKVEYQ CEGFLEKNKD TVFEEQIKVL KSSKFKMLPE LFQDDEKAIS 600
PTSATSSGRT PLTRTPAKPT KGRPGQMAKE HKKTVGHQFR NSLHLLMETL NATTPHYVRC 660
IKPNDFKFPF TFDEKRAVQQ LRACGVLETI RISAAGFPSR WTYQEFFSRY RVLMKQKDVL 720
SDRKQTCKNV LEKLILDKDK YQFGKTKIFF RAGQVAYLEK LRADKLRAAC IRIQKTIRGW 780
LLRKKYLRMR KAAITMQRYV RGYQARCYAK FLRRTKAATI IQKYWRMYVV RRRYKIRRAA 840
TIVLQSYLRG FLARNRYRKI LREHKAVIIQ KRVRGWLART HYKRSMHAII YLQCCFRRMM 900
AKRELKKLKI EARSVERYKK LHIGMENKIM QLQRKVDEQN KDYKCLVEKL TNLEGIYNSE 960
TEKLRSDLER LQLSEEEAKV ATGRVLSLQE EIAKLRKDLE QTRSEKKCIE EHADRYKQET 1020
EQLVSNLKEE NTLLKQEKEA LNHRIVQQAK EMTETMEKKL VEETKQLELD LNDERLRYQN 1080
LLNEFSRLEE RYDDLKEEMT LMVHVPKPGH KRTDSTHSSN ESEYIFSSEI AEMEDIPSRT 1140
EEPSEKKVPL DMSLFLKLQK RVTELEQEKQ VMQDELDRKE EQVLRSKAKE EERPQIRGAE 1200
LEYESLKRQE LESENKKLKN ELNELRKALS EKSAPEVTAP GAPAYRVLME QLTSVSEELD 1260
VRKEEVLILR SQLVSQKEAI QPKLHENTMT DSTILLEDVQ KMKDKGEIAQ AYIGLKETNR 1320
SSALDYHELN EDGELWLVYE GLKQANRLLE SQLQSQKRSH ENEAEALRGE IQSLKEENNR 1380
QQQLLAQNLQ LPPEARIEAS LQHEITRLTN ENLYFEELYA DDPKKYQSYR ISLYKRMIDL 1440
MEQLEKQDKT VRKLKKQLKV FAKKIGELEV GQMENISPGQ IIDEPIRPVN IPRKEKDFQG 1500
MLEYKKEDEQ KLVKNLILEL KPRGVAVNLI PGLPAYILFM CVRHADYLND DQKVRSLLTS 1560
TINSIKKVLK KRGDDFETVS FWLSNTCRFL HCLKQYSGEE GFMKHNTSRQ NEHCLTNFDL 1620
AEYRQVLSDL AIQIYQQLVR VLENILQPMI VSGMLEHETI QGVSGVKPTG LRKRTSSIAD 1680
EGTYTLDSIL RQLNSFHSVM CQHGMDPELI KQVVKQMFYI IGAITLNNLL LRKDMCSWSK 1740
GMQIRYNVSQ LEEWLRDKNL MNSGAKETLE PLIQAAQLLQ VKKKTDDDAE AICSMCNALT 1800
TAQIVKVLNL YTPVNEFEER VSVSFIRTIQ MRLRDRKDSP QLLMDAKHIF PVTFPFNPSS 1860
LALETIQIPA SLGLGFISRV 1880 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR018444; Dil_domain.
 IPR002710; Dilute.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01843; DIL
 PF00612; IQ
 PF00063; Myosin_head 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS51126; DILUTE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.