CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027941
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin 1, type 1, E-cadherin (Epithelial), isoform CRA_c 
Protein Synonyms/Alias
 E-cadherin; Fizzy-related protein homolog; Uncharacterized protein 
Gene Name
 CDH1 
Gene Synonyms/Alias
 hCG_28201 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
677LRRRAVVKEPLLPPEubiquitination[1]
810EWGNRFKKLADMYGGubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Cadherins are calcium dependent cell adhesion proteins (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Cell adhesion; Cell membrane; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 821 AA 
Protein Sequence
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 60
TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 120
HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 180
NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 240
AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 300
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 360
AVITVTDTND NPPIFNPTTG LDFEAKQQYI LHVAVTNVVP FEVSLTTSTA TVTVDVLDVN 420
EAPIFVPPEK RVEVSEDFGV GQEITSYTAQ EPDTFMEQKI TYRIWRDTAN WLEINPDTGA 480
ISTRAELDRE DFEHVKNSTY TALIIATDNG SPVATGTGTL LLILSDVNDN APIPEPRTIF 540
FCERNPKPQV INIIDADLPP NTSPFTAELT HGASANWTIQ YNDPTQESII LKPKMALEVG 600
DYKINLKLMD NQNKDQVTTL EVSVCDCEGA AGVCRKAQPV EAGLQIPAIL GILGGILALL 660
ILILLLLLFL RRRAVVKEPL LPPEDDTRDN VYYYDEEGGG EEDQDFDLSQ LHRGLDARPE 720
VTRNDVAPTL MSVPRYLPRP ANPDEIGNFI DENLKAADTD PTAPPYDSLL VFDYEGSGSE 780
AASLSSLNSS ESDKDQDYDY LNEWGNRFKK LADMYGGGED D 821 
Gene Ontology
 GO:0016235; C:aggresome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.