UniProt Accession

 CALU_HUMAN; O43852; B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; O60456; Q6FHB9; Q96RL3; Q9NR43 

Genbank Protein ID

 U67280; AF013759; AF345637; HM002604; HM002605; HM002606; HM002607; HM002608; HM002609; HM002610; HM002611; HM002612; HM002613; HM002614; HM002615; HM002616; AK056338; CR541835; AC024952; CH471070; BC013383; AF257659 

Genbank Nucleotide ID

 AAB97725.1; AAC17216.1; AAK72908.1; ADG45004.1; ADG45005.1; ADG45006.1; ADG45007.1; ADG45008.1; ADG45009.1; ADG45010.1; ADG45011.1; ADG45012.1; ADG45013.1; ADG45014.1; ADG45015.1; ADG45016.1; BAG51681.1; CAG46634.1; EAW83679.1; AAH13383.1; AAF76141.1 

Protein Name

 Calumenin 

Protein Synonyms/Alias

 Crocalbin; IEF SSP 9302 

Gene Name

 CALU 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
94	FVTEGELKSWIKHAQ	ubiquitination	[1]
150	PDDGFNYKQMMVRDE	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). 

Sequence Annotation

 DOMAIN 68 103 EF-hand 1.
 DOMAIN 104 139 EF-hand 2.
 DOMAIN 151 186 EF-hand 3.
 DOMAIN 188 223 EF-hand 4.
 DOMAIN 229 264 EF-hand 5.
 DOMAIN 265 300 EF-hand 6.
 MOTIF 312 315 Prevents secretion from ER (By
 MOD_RES 44 44 Phosphoserine.
 MOD_RES 65 65 Phosphothreonine.
 CARBOHYD 131 131 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Sarcoplasmic reticulum; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; TAS:ProtInc.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IDA:UniProtKB.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome. 

Interpro

 IPR027239; Calumenin.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS