CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010256
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable diguanylate cyclase YedQ 
Protein Synonyms/Alias
 DGC; Cellulose synthesis regulatory protein 
Gene Name
 yedQ 
Gene Synonyms/Alias
 b1956; JW5832 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
415NRGALFEKARPLAKLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Involved in the regulation of cellulose production. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria. 
Sequence Annotation
 DOMAIN 428 563 GGDEF.
 ACT_SITE 479 479 Proton acceptor (Potential).
 METAL 436 436 Magnesium (By similarity).
 METAL 479 479 Magnesium (By similarity).
 BINDING 444 444 Substrate (By similarity).
 BINDING 453 453 Substrate (By similarity).  
Keyword
 Cell inner membrane; Cell membrane; Cellulose biosynthesis; Complete proteome; GTP-binding; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 564 AA 
Protein Sequence
MQHETKMENQ SWLKKLARRL GPGHVVNLCF IVVLLFSTLL TWREVVVLED AYISSQRNHL 60
ENVANALDKH LQYNVDKLIF LRNGMREALV APLDFTSLRD AVTEFEQHRD EHAWKIELNR 120
RRTLPVNGVS DALVSEGNLL SRENESLDNE ITAALEVGYL LRLAHNSSSM VEQAMYVSRA 180
GFYVSTQPTL FTRNVPTRYY GYVTQPWFIG HSQRENRHRA VRWFTSQPEH ASNTEPQVTV 240
SVPVDSNNYW YGVLGMSIPV RTMQQFLRNA IDKNLDGEYQ LYDSKLRFLT SSNPDHPTGN 300
IFDPRELALL AQAMEHDTRG GIRMDSRYVS WERLDHFDGV LVRVHTLSEG VRGDFGSISI 360
ALTLLWALFT TMLLISWYVI RRMVSNMYVL QSSLQWQAWH DTLTRLYNRG ALFEKARPLA 420
KLCQTHQHPF SVIQVDLDHF KAINDRFGHQ AGDRVLSHAA GLISSSLRAQ DVAGRVGGEE 480
FCVILPGASL TEAAEVAERI RLKLNEKEML IAKSTTIRIS ASLGVSSSEE TGDYDFEQLQ 540
SLADRRLYLA KQAGRNRVFA SDNA 564 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0052621; F:diguanylate cyclase activity; IGI:EcoCyc.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
 GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
 GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:2000154; P:negative regulation of flagellar cell motility; IMP:EcoCyc. 
Interpro
 IPR001054; A/G_cyclase.
 IPR000160; GGDEF_dom. 
Pfam
 PF00990; GGDEF 
SMART
 SM00267; GGDEF 
PROSITE
 PS50887; GGDEF 
PRINTS