CPLM-001083

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001083

UniProt Accession

Genbank Protein ID

U06431; U83434; U83427; U83428; U83429; U83430; U83431; U83432; U83433; Y16524; Y16525; Y16526; Y16527; Y16528; Y16529; Y16530; Y16531; Y16532

Genbank Nucleotide ID

AAA67440.1; AAC53585.1; AAC53585.1; AAC53585.1; AAC53585.1; AAC53585.1; AAC53585.1; AAC53585.1; AAC53585.1; CAA76272.1; CAA76272.1; CAA76272.1; CAA76272.1; CAA76272.1; CAA76272.1; CAA76272.1; CAA76272.1; CAA76272.1

Protein Name

Polymeric immunoglobulin receptor

Protein Synonyms/Alias

PIgR; Poly-Ig receptor; Secretory component

Gene Name

Pigr

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
694	DISMADFKNSRDLGG	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).

Sequence Annotation

DOMAIN 21 120 Ig-like V-type 1.
DOMAIN 135 237 Ig-like V-type 2.
DOMAIN 245 351 Ig-like V-type 3.
DOMAIN 352 457 Ig-like V-type 4.
DOMAIN 463 563 Ig-like V-type 5.
MOD_RES 741 741 Phosphoserine.
CARBOHYD 90 90 N-linked (GlcNAc...) (Potential).
CARBOHYD 147 147 N-linked (GlcNAc...) (Potential).
CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).
CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
CARBOHYD 420 420 N-linked (GlcNAc...) (Potential).
CARBOHYD 471 471 N-linked (GlcNAc...) (Potential).
DISULFID 40 110 Potential.
DISULFID 152 220 Potential.
DISULFID 257 324 Potential.
DISULFID 370 440 Potential.
DISULFID 484 546 Potential.

Keyword

Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

771 AA

Protein Sequence

MRLYLFTLLV TVFSGVSTKS PIFGPQEVSS IEGDSVSITC YYPDTSVNRH TRKYWCRQGA 60
SGMCTTLISS NGYLSKEYSG RANLINFPEN NTFVINIEQL TQDDTGSYKC GLGTSNRGLS 120
FDVSLEVSQV PELPSDTHVY TKDIGRNVTI ECPFKRENAP SKKSLCKKTN QSCELVIDST 180
EKVNPSYIGR AKLFMKGTDL TVFYVNISHL THNDAGLYIC QAGEGPSADK KNVDLQVLAP 240
EPELLYKDLR SSVTFECDLG REVANEAKYL CRMNKETCDV IINTLGKRDP DFEGRILITP 300
KDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPIQT WQLFVNEEST IPNRRSVVKG 360
VTGGSVAIAC PYNPKESSSL KYWCRWEGDG NGHCPVLVGT QAQVQEEYEG RLALFDQPGN 420
GTYTVILNQL TTEDAGFYWC LTNGDSRWRT TIELQVAEAT REPNLEVTPQ NATAVLGETF 480
TVSCHYPCKF YSQEKYWCKW SNKGCHILPS HDEGARQSSV SCDQSSQLVS MTLNPVSKED 540
EGWYWCGVKQ GQTYGETTAI YIAVEERTRG SSHVNPTDAN ARAKVALEEE VVDSSISEKE 600
NKAIPNPGPF ANEREIQNVG DQAQENRASG DAGSADGQSR SSSSKVLFST LVPLGLVLAV 660
GAIAVWVARV RHRKNVDRMS ISSYRTDISM ADFKNSRDLG GNDNMGASPD TQQTVIEGKD 720
EIVTTTECTA EPEESKKAKR SSKEEADMAY SAFLLQSSTI AAQVHDGPQE A 771

Gene Ontology

GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.

Interpro

IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.

Pfam

PF07686; V-set

SMART

SM00409; IG

PROSITE

PS50835; IG_LIKE

PRINTS