CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012247
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Desmoglein-2 
Protein Synonyms/Alias
 Cadherin family member 5; HDGC 
Gene Name
 DSG2 
Gene Synonyms/Alias
 CDHF5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
195EPNTLNSKISYRIVSubiquitination[1, 2]
376KPTPIPIKVKVKNVKubiquitination[3, 4]
561VLLQQSEKKLGRSEIubiquitination[1]
667EGAPPEDKVVPSFLPubiquitination[1, 2, 5]
697MAKEATMKGSSSASIubiquitination[1, 2]
706SSSASIVKGQHEMSEubiquitination[1, 3, 4, 5]
746IMTTETTKTARATGAubiquitination[1, 2, 3, 4, 5, 6, 7]
779LRNYFTDKAASYTEEubiquitination[1]
832FLDDLGLKFKTLAEVubiquitination[1, 3, 4, 8]
844AEVCLGQKIDINKEIubiquitination[2]
849GQKIDINKEIEQRQKubiquitination[2]
901LQEANAEKVTQEIVTubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [7] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [8] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. 
Sequence Annotation
 DOMAIN 50 160 Cadherin 1.
 DOMAIN 161 273 Cadherin 2.
 DOMAIN 274 388 Cadherin 3.
 DOMAIN 389 503 Cadherin 4.
 REPEAT 881 912 Desmoglein repeat 1.
 REPEAT 913 942 Desmoglein repeat 2.
 REPEAT 943 968 Desmoglein repeat 3.
 REPEAT 969 992 Desmoglein repeat 4.
 REPEAT 993 1021 Desmoglein repeat 5.
 REPEAT 1022 1051 Desmoglein repeat 6.
 MOD_RES 680 680 Phosphoserine.
 MOD_RES 703 703 Phosphoserine.
 MOD_RES 1118 1118 Phosphoserine.
 CARBOHYD 112 112 N-linked (GlcNAc...).
 CARBOHYD 182 182 N-linked (GlcNAc...).
 CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
 CARBOHYD 462 462 N-linked (GlcNAc...).
 CARBOHYD 514 514 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Calcium; Cardiomyopathy; Cell adhesion; Cell junction; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Disease mutation; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1118 AA 
Protein Sequence
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA WITAPVALRE 60
GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG IFVFNKDTGE LNVTSILDRE 120
ETPFFLLTGY ALDARGNNVE KPLELRIKVL DINDNEPVFT QDVFVGSVEE LSAAHTLVMK 180
INATDADEPN TLNSKISYRI VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE 240
ARDGNGEVTD KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE 300
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF SVIVANKAAF 360
HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES MDRSSKGQII GNFQAFDEDT 420
GLPAHARYVK LEDRDNWISV DSVTSEIKLA KLPDFESRYV QNGTYTVKIV AISEDYPRKT 480
ITGTVLINVE DINDNCPTLI EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM 540
AEKWKIARQE STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR 600
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT IEMLHPWNNE 660
GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS SASIVKGQHE MSEMDGRWEE 720
HRSLLSGRAT QFTGATGAIM TTETTKTARA TGASRDMAGA QAAAVALNEE FLRNYFTDKA 780
ASYTEEDENH TAKDCLLVYS QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC 840
LGQKIDINKE IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE 900
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT VILGPSQPQS 960
LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN PLEGTQHLQD VPYVMVRERE 1020
SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV LAPASTLQSS YQIPTENSMT ARNTTVSGAG 1080
VPGPLPDFGL EESGHSNSTI TTSSTRVTKH STVQHSYS 1118 
Gene Ontology
 GO:0005911; C:cell-cell junction; TAS:ProtInc.
 GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IMP:BHF-UCL.
 GO:0007155; P:cell adhesion; IDA:UniProtKB.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IMP:BHF-UCL. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR027397; Catenin_binding_dom.
 IPR009123; Desmoglein.
 IPR009122; Desmosomal_cadherin. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.
 PR01818; DESMOCADHERN.
 PR01819; DESMOGLEIN.