UniProt Accession

 H0YGW8_HUMAN; H0YGW8 

Genbank Protein ID

 AC135056 

Genbank Nucleotide ID

  

Protein Name

 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like 

Protein Synonyms/Alias

  

Gene Name

 DUS1L 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	LSVPVTCKIRVFPEI	ubiquitination	[1]
24	RVFPEIDKTVRYAQM	ubiquitination	[1]
34	RYAQMLEKAGCQLLT	ubiquitination	[1]
63	AASWEHIKAVRKAVA	ubiquitination	[1, 2]
177	AAVSQELKLRCQEEI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0017150; F:tRNA dihydrouridine synthase activity; IEA:InterPro.
 GO:0002943; P:tRNA dihydrouridine synthesis; IEA:GOC. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR001269; tRNA_hU_synthase. 

Pfam

 PF01207; Dus 

SMART

  

PROSITE

  

PRINTS