UniProt Accession

 KBTBB_HUMAN; O94819; Q3L1I0 

Genbank Protein ID

 AY762229; AB018254; CH471181 

Genbank Nucleotide ID

 AAW83120.1; BAA34431.2; EAW51487.1 

Protein Name

 Kelch repeat and BTB domain-containing protein 11 

Protein Synonyms/Alias

 Chronic myelogenous leukemia-associated protein; Kelch domain-containing protein 7B 

Gene Name

 KBTBD11 

Gene Synonyms/Alias

 CMLAP; KIAA0711; KLHDC7C 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
244	YEVLSAAKRQRLNEL	ubiquitination	[1, 2, 3]
472	SLFYRLLKYDPRRDE	ubiquitination	[2, 3]
532	SRYHCLAKQWSPCVA	ubiquitination	[2]
614	FALSLPEKPPRGEQG	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

 DOMAIN 140 196 BTB.
 REPEAT 311 359 Kelch 1.
 REPEAT 360 412 Kelch 2.
 REPEAT 413 455 Kelch 3.
 REPEAT 458 500 Kelch 4.
 MOD_RES 64 64 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Kelch repeat; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 623 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 

Pfam

 PF00651; BTB
 PF01344; Kelch_1 

SMART

 SM00225; BTB
 SM00612; Kelch 

PROSITE

 PS50097; BTB 

PRINTS