CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017901
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-directed RNA polymerase subunit beta' 
Protein Synonyms/Alias
 RNAP subunit beta'; RNA polymerase subunit beta'; Transcriptase subunit beta' 
Gene Name
 rpoC 
Gene Synonyms/Alias
 TTHA1812 
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
1490FTQVVDQKTLKAIEEacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841
Functional Description
 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome; Transcription; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1524 AA 
Protein Sequence
MKKEVRKVRI ALASPEKIRS WSYGEVEKPE TINYRTLKPE RDGLFDERIF GPIKDYECAC 60
GKYKRQRFEG KVCERCGVEV TKSIVRRYRM GHIELATPAA HIWFVKDVPS KIGTLLDLSA 120
TELEQVLYFS KYIVLDPKGA ILNGVPVEKR QLLTDEEYRE LRYGKQETYP LPPGVDALVK 180
DGEEVVKGQE LAPGVVSRLD GVALYRFPRR VRVEYVKKER AGLRLPLAAW VEKEAYKPGE 240
ILAELPEPYL FRAEEEGVVE LKELEEGAFL VLRREDEPVA TYFLPVGMTP LVVHGEIVEK 300
GQPLAEAKGL LRMPRQVRAA QVEAEEEGET VYLTLFLEWT EPKDYRVQPH MNVVVPEGAR 360
VEAGDKIVAA IDPEEEVIAE AEGVVHLHEP ASILVVKARV YPFEDDVEVS TGDRVAPGDV 420
LADGGKVKSD VYGRVEVDLV RNVVRVVESY DIDARMGAEA IQQLLKELDL EALEKELLEE 480
MKHPSRARRA KARKRLEVVR AFLDSGNRPE WMILEAVPVL PPDLRPMVQV DGGRFATSDL 540
NDLYRRLINR NNRLKKLLAQ GAPEIIIRNE KRMLQEAVDA LLDNGRRGAP VTNPGSDRPL 600
RSLTDILSGK QGRFRQNLLG KRVDYSGRSV IVVGPQLKLH QCGLPKRMAL ELFKPFLLKK 660
MEEKGIAPNV KAARRMLERQ RDIKDEVWDA LEEVIHGKVV LLNRAPTLHR LGIQAFQPVL 720
VEGQSIQLHP LVCEAFNADF DGDQMAVHVP LSSFAQAEAR IQMLSAHNLL SPASGEPLAK 780
PSRDIILGLY YITQVRKEKK GAGLEFATPE EALAAHERGE VALNAPIKVA GRETSVGRLK 840
YVFANPDEAL LAVAHGIVDL QDVVTVRYMG KRLETSPGRI LFARIVAEAV EDEKVAWELI 900
QLDVPQEKNS LKDLVYQAFL RLGMEKTARL LDALKYYGFT FSTTSGITIG IDDAVIPEEK 960
KQYLEEADRK LLQIEQAYEM GFLTDRERYD QILQLWTETT EKVTQAVFKN FEENYPFNPL 1020
YVMAQSGARG NPQQIRQLCG LRGLMQKPSG ETFEVPVRSS FREGLTVLEY FISSHGARKG 1080
GADTALRTAD SGYLTRKLVD VTHEIVVREA DCGTTNYISV PLFQPDEVTR SLRLRKRADI 1140
EAGLYGRVLA REVEVLGVRL EEGRYLSMDD VHLLIKAAEA GEIQEVPVRS PLTCQTRYGV 1200
CQKCYGYDLS MARPVSIGEA VGIVAAQSIG EPGTQLTMRT FHTGGVAGAA DITQGLPRVI 1260
ELFEARRPKA KAVISEIDGV VRIEETEEKL SVFVESEGFS KEYKLPKEAR LLVKDGDYVE 1320
AGQPLTRGAI DPHQLLEAKG PEAVERYLVE EIQKVYRAQG VKLHDKHIEI VVRQMMKYVE 1380
VTDPGDSRLL EGQVLEKWDV EALNERLIAE GKTPVAWKPL LMGVTKSALS TKSWLSAASF 1440
QNTTHVLTEA AIAGKKDELI GLKENVILGR LIPAGTGSDF VRFTQVVDQK TLKAIEEARK 1500
EAVEAKERPA ARRGVKREQP GKQA 1524 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:HAMAP.
 GO:0006351; P:transcription, DNA-dependent; IEA:HAMAP. 
Interpro
 IPR009010; Asp_de-COase-like_dom.
 IPR012754; DNA-dir_RpoC_beta_prime.
 IPR000722; RNA_pol_asu.
 IPR006592; RNA_pol_N.
 IPR007080; RNA_pol_Rpb1_1.
 IPR007066; RNA_pol_Rpb1_3.
 IPR007083; RNA_pol_Rpb1_4.
 IPR007081; RNA_pol_Rpb1_5. 
Pfam
 PF04997; RNA_pol_Rpb1_1
 PF00623; RNA_pol_Rpb1_2
 PF04983; RNA_pol_Rpb1_3
 PF05000; RNA_pol_Rpb1_4
 PF04998; RNA_pol_Rpb1_5 
SMART
 SM00663; RPOLA_N 
PROSITE
  
PRINTS