CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bardet-Biedl syndrome 2 protein homolog 
Protein Synonyms/Alias
  
Gene Name
 Bbs2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
325LPGTAEMKGNLLDTSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity). 
Sequence Annotation
  
Keyword
 Cell membrane; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 721 AA 
Protein Sequence
MLLPVFTLKL RHKISPRMVA IGRYDGTHPC LAAATQAGKV FIHNPHTRSQ HFSASRVFQS 60
PLESDVSLLN INQTVSCLGS GVLNPELGYD TLLVGTQTSL LAYDIYNNSD LFYREVSDGA 120
NAIVLGTLGD IAPPLAIIGG NCALQGFDHE GNDLFWTVTG DNVHSLALCD FDGDGKTELL 180
VGSEDFDIRV FKEDEIVAEM TETEIVTSLC PMYGSRFGYA LSNGTVGVYD KTARYWRIKS 240
KNHAMSIHAF DINSDGVCEL ITGWSNGKVD ARSDRTGEVI FKDNFSSAVA GVVEGDYRMD 300
GHVQLICCSV DGEIRGYLPG TAEMKGNLLD TSVEQDLIRE LSQKKQNLLL ELRNYEESTK 360
AELSSPLNEA DGQKGIIPAN TRLHTALSVN MGNDLQDAHA ELGISTSNDT IIRAVLIFAE 420
GIFVGESHVV HPSIHNLSSS LRVPITPPKD VPVDLHLKTF VGYRSSTQFH VFELTRQLPR 480
FTMYALTSPD AASEPVSYVN FSVAERTQRM VTWLNQNFLL PEDSNVQNSP FHVCFTSLRN 540
GGQLYIKMKQ SGEITVNTDD IDLAGDIIQS IASFFAIEDL QVEADFPVYF EELRKVLVKV 600
DEYHSVHQKL SADMADNSNL IRSLLVRAED ARLMRDMKTM KSRYMELYDL NKDLLNGYKI 660
RCNNHTELLG NLKAVNQAIQ RAGRLRVGKP KNQVISACRD AIRSNNINTL FRIMRVGTAP 720
S 721 
Gene Ontology
 GO:0034464; C:BBSome; IDA:MGI.
 GO:0060170; C:cilium membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; IEA:Compara.
 GO:0031514; C:motile cilium; IMP:BHF-UCL.
 GO:0030534; P:adult behavior; IMP:MGI.
 GO:0014824; P:artery smooth muscle contraction; IMP:MGI.
 GO:0048854; P:brain morphogenesis; IMP:MGI.
 GO:0051216; P:cartilage development; IMP:MGI.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0045444; P:fat cell differentiation; IEP:BHF-UCL.
 GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara.
 GO:0021766; P:hippocampus development; IMP:MGI.
 GO:0038108; P:negative regulation of appetite by leptin-mediated signaling pathway; IMP:BHF-UCL.
 GO:0010629; P:negative regulation of gene expression; IMP:MGI.
 GO:0040015; P:negative regulation of multicellular organism growth; IMP:MGI.
 GO:0045494; P:photoreceptor cell maintenance; IMP:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0033365; P:protein localization to organelle; IDA:BHF-UCL.
 GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; IMP:BHF-UCL.
 GO:0007288; P:sperm axoneme assembly; IMP:MGI.
 GO:0021756; P:striatum development; IMP:MGI.
 GO:0042311; P:vasodilation; IMP:MGI. 
Interpro
 IPR016616; Bardet-Biedl_syndrome_2_prot.
 IPR013517; FG-GAP.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF01839; FG-GAP 
SMART
  
PROSITE
  
PRINTS