UniProt Accession

 MAG_RAT; P07722; P02685; P07723 

Genbank Protein ID

 M14871; M22357; M16800; X05301; M11721; M36702; V01544 

Genbank Nucleotide ID

 AAA41556.1; AAA41558.1; AAA41557.1; CAA28920.1; AAA42082.1; AAA40831.1; CAA24786.1 

Protein Name

 Myelin-associated glycoprotein 

Protein Synonyms/Alias

 Brain neuron cytoplasmic protein 3; Sialic acid-binding Ig-like lectin 4a; Siglec-4a 

Gene Name

 Mag 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
570	RISGAPDKYESEKRL	acetylation	[1]
570	RISGAPDKYESEKRL	ubiquitination	[2]
575	PDKYESEKRLGSERR	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity). 

Sequence Annotation

 DOMAIN 22 120 Ig-like V-type.
 DOMAIN 139 237 Ig-like C2-type 1.
 DOMAIN 241 325 Ig-like C2-type 2.
 DOMAIN 327 412 Ig-like C2-type 3.
 DOMAIN 413 508 Ig-like C2-type 4.
 BINDING 118 118 Sialic acid (By similarity).
 LIPID 531 531 S-palmitoyl cysteine.
 CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).
 CARBOHYD 223 223 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...) (Potential).
 CARBOHYD 332 332 N-linked (GlcNAc...) (Potential).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 CARBOHYD 450 450 N-linked (GlcNAc...) (Potential).
 CARBOHYD 454 454 N-linked (GlcNAc...) (Potential).
 DISULFID 37 165 Probable.
 DISULFID 42 100 Probable.
 DISULFID 159 217 Probable.
 DISULFID 261 305 Probable.
 DISULFID 347 392 Probable.
 DISULFID 421 430 Probable.
 DISULFID 432 488 Probable.  

Keyword

 Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lectin; Lipoprotein; Membrane; Palmitate; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 626 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033270; C:paranode region of axon; IEA:Compara.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 

Pfam

 PF08205; C2-set_2
 PF07679; I-set 

SMART

 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50835; IG_LIKE 

PRINTS