UniProt Accession

 STMN2_HUMAN; Q93045; A8K9M2; G3V110; O14952; Q6PK68 

Genbank Protein ID

 S82024; D50375; BT020034; CR456833; AK292737; AC016240; AC025599; CH471068; CH471068; BC006302; BQ069488 

Genbank Nucleotide ID

 AAB36428.1; BAA23326.1; AAV38837.1; CAG33114.1; BAF85426.1; EAW87064.1; EAW87065.1; AAH06302.1 

Protein Name

 Stathmin-2 

Protein Synonyms/Alias

 Superior cervical ganglion-10 protein; Protein SCG10 

Gene Name

 STMN2 

Gene Synonyms/Alias

 SCG10; SCGN10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	QAFELILKPPSPISE	ubiquitination	[1]
86	LSLEEIQKKLEAAEE	ubiquitination	[1, 2, 3]
119	HEREVLQKALEENNN	ubiquitination	[1, 4, 5]
129	EENNNFSKMAEEKLI	ubiquitination	[1, 4, 5]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). 

Sequence Annotation

 DOMAIN 38 179 SLD.
 REGION 1 26 Membrane attachment (Potential).
 REGION 39 96 Regulatory/phosphorylation domain
 MOD_RES 16 16 Phosphoserine (Potential).
 MOD_RES 50 50 Phosphoserine (Potential).
 MOD_RES 62 62 Phosphoserine (By similarity).
 MOD_RES 73 73 Phosphoserine (By similarity).
 MOD_RES 97 97 Phosphoserine (Potential).
 LIPID 22 22 S-palmitoyl cysteine.
 LIPID 24 24 S-palmitoyl cysteine.  

Keyword

 Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Golgi apparatus; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0007026; P:negative regulation of microtubule depolymerization; IDA:UniProtKB.
 GO:0031115; P:negative regulation of microtubule polymerization; IDA:UniProtKB.
 GO:0010977; P:negative regulation of neuron projection development; IDA:UniProtKB.
 GO:0030182; P:neuron differentiation; NAS:UniProtKB.
 GO:0031117; P:positive regulation of microtubule depolymerization; IDA:UniProtKB.
 GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB. 

Interpro

 IPR026729; Stathmin-2.
 IPR000956; Stathmin_fam. 

Pfam

 PF00836; Stathmin 

SMART

  

PROSITE

 PS00563; STATHMIN_1
 PS01041; STATHMIN_2
 PS51663; STATHMIN_3 

PRINTS

 PR00345; STATHMIN.