UniProt Accession

 KLC1_HUMAN; Q07866; A6NF62; F8VTM4; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62 

Genbank Protein ID

 L04733; AY180163; AY180164; AY180165; AY180166; AY180168; AY180167; AY180169; AY180170; AY244715; AF267530; AF267518; AF267519; AF267520; AF267521; AF267522; AF267523; AF267524; AF267525; AF267526; AF267527; AF267528; AF267529; AL049840; AL139300; CH471061; BC008881; BK000681; BK000682; BK000684; BK001163; BK001165; BK001166; BK001169; BK001170; BK001171 

Genbank Nucleotide ID

 AAA16576.1; AAO62548.1; AAO62549.1; AAO62550.1; AAO62551.1; AAO62553.1; AAO62552.1; AAO62554.1; AAO62555.1; AAO64641.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; AAF72543.1; EAW81834.1; AAH08881.1; DAA01265.1; DAA01266.1; DAA01268.1; DAA01289.1; DAA01291.1; DAA01292.1; DAA01295.1; DAA01296.1; DAA01297.1 

Protein Name

 Kinesin light chain 1 

Protein Synonyms/Alias

 KLC 1 

Gene Name

 KLC1 

Gene Synonyms/Alias

 KLC; KNS2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
309	NLAVLYGKRGKYKEA	ubiquitination	[1]
393	NLASCYLKQGKFKQA	acetylation	[2]
518	NDPENMEKRRSRESL	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. 

Sequence Annotation

 REPEAT 213 246 TPR 1.
 REPEAT 255 288 TPR 2.
 REPEAT 297 330 TPR 3.
 REPEAT 339 372 TPR 4.
 REPEAT 381 414 TPR 5.
 REPEAT 464 497 TPR 6.
 MOD_RES 162 162 Phosphoserine (By similarity).
 MOD_RES 449 449 Phosphotyrosine (By similarity).
 MOD_RES 521 521 Phosphoserine; by AMPK.
 MOD_RES 524 524 Phosphoserine; by AMPK.  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Host-virus interaction; Microtubule; Motor protein; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 573 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:HGNC.
 GO:0005871; C:kinesin complex; ISS:HGNC.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0003774; F:motor activity; TAS:ProtInc.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007018; P:microtubule-based movement; TAS:Reactome.
 GO:0035617; P:stress granule disassembly; ISS:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR002151; Kinesin_light.
 IPR015792; Kinesin_light_repeat.
 IPR015390; Rabaptin_Rab5-bd_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF09311; Rab5-bind
 PF00515; TPR_1
 PF07719; TPR_2 

SMART

 SM00028; TPR 

PROSITE

 PS01160; KINESIN_LIGHT
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS

 PR00381; KINESINLIGHT.