UniProt Accession

 STEA2_HUMAN; Q8NFT2; A4D1F1; G5E9C6; Q6UXN6; Q6YPB1; Q8IUE7 

Genbank Protein ID

 AY008444; AY008445; AF455138; AF526382; AY358267; AC002064; AC004969; CH236949; CH471091; CH471091 

Genbank Nucleotide ID

 AAG32148.1; AAG32149.1; AAN04080.1; AAQ08976.1; AAQ88634.1; EAL24165.1; EAW76890.1; EAW76894.1 

Protein Name

 Metalloreductase STEAP2 

Protein Synonyms/Alias

 Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1 

Gene Name

 STEAP2 

Gene Synonyms/Alias

 PCANAP1; STAMP1; UNQ6507/PRO23203 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	VIGSRNPKFASEFFP	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). 

Sequence Annotation

 DOMAIN 259 407 Ferric oxidoreductase.
 METAL 316 316 Iron (heme axial ligand) (By similarity).
 METAL 409 409 Iron (heme axial ligand) (By similarity).  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Copper; Electron transport; Endosome; FAD; Flavoprotein; Ion transport; Iron; Iron transport; Membrane; Metal-binding; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0030140; C:trans-Golgi network transport vesicle; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0005215; F:transporter activity; IDA:UniProtKB.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006897; P:endocytosis; IDA:UniProtKB.
 GO:0006893; P:Golgi to plasma membrane transport; IDA:UniProtKB.
 GO:0006811; P:ion transport; IEA:UniProtKB-KW.
 GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
 GO:0045055; P:regulated secretory pathway; IDA:UniProtKB.
 GO:0009725; P:response to hormone stimulus; IDA:UniProtKB. 

Interpro

 IPR013130; Fe3_Rdtase_TM_dom.
 IPR016040; NAD(P)-bd_dom.
 IPR004455; NADP_OxRdtase_F420. 

Pfam

 PF03807; F420_oxidored
 PF01794; Ferric_reduct 

SMART

  

PROSITE

  

PRINTS