UniProt Accession

 PRS4_MOUSE; P62192; P49014; Q03527; Q96AZ3 

Genbank Protein ID

 U39302; BC003860 

Genbank Nucleotide ID

 AAB34137.1; AAH03860.1 

Protein Name

 26S protease regulatory subunit 4 

Protein Synonyms/Alias

 P26s4; 26S proteasome AAA-ATPase subunit RPT2; Proteasome 26S subunit ATPase 1 

Gene Name

 Psmc1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	DDKDKKKKYEPPVPT	ubiquitination	[1]
48	KGPDAASKLPLVTPH	ubiquitination	[1]
69	LLKLERIKDYLLMEE	ubiquitination	[1]
91	QMKPLEEKQEEERSK	ubiquitination	[1]
98	KQEEERSKVDDLRGT	ubiquitination	[1]
178	VTVMKVEKAPQETYA	ubiquitination	[1]
232	YGPPGTGKTLLAKAV	ubiquitination	[1]
237	TGKTLLAKAVANQTS	acetylation	[2]
237	TGKTLLAKAVANQTS	ubiquitination	[1]
258	VGSELIQKYLGDGPK	acetylation	[2, 3]
258	VGSELIQKYLGDGPK	ubiquitination	[1]
265	KYLGDGPKLVRELFR	ubiquitination	[1]
293	EIDAIGTKRYDSNSG	ubiquitination	[1]
359	EFPLPDEKTKKRIFQ	ubiquitination	[1]
387	LDDLIMAKDDLSGAD	ubiquitination	[1]
396	DLSGADIKAICTEAG	ubiquitination	[1]
423	NEDFKKSKENVLYKK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 

Sequence Annotation

 NP_BIND 226 233 ATP (Potential).
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 258 258 N6-acetyllysine (By similarity).
 MOD_RES 439 439 Phosphotyrosine (By similarity).
 LIPID 2 2 N-myristoyl glycine.
 CROSSLNK 237 237 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Lipoprotein; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0030163; P:protein catabolic process; IEA:InterPro. 

Interpro

 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS