| Tag | Content |
|---|
| CPLM ID | CPLM-003962 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytochrome P450 2D9 |
Protein Synonyms/Alias | CYPIID9; Cytochrome P450-16-alpha; Cytochrome P450CA; Testosterone 16-alpha hydroxylase |
Gene Name | Cyp2d9 |
Gene Synonyms/Alias | Cyp2d-9 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 150 | RNFGLGKKSLEDWVT | ubiquitination | [1] | | 242 | RIPRLADKALQGQKS | ubiquitination | [1] | | 248 | DKALQGQKSFIAILD | ubiquitination | [1] | | 284 | AFLAEIEKAKGNPES | ubiquitination | [1] | | 286 | LAEIEKAKGNPESSF | ubiquitination | [1] | | 394 | VQDFLIPKGTILLPN | ubiquitination | [1] | | 407 | PNMSSMLKDESVWEK | ubiquitination | [1] | | 414 | KDESVWEKPLRFHPE | ubiquitination | [1] | | 432 | DAQGHFVKPEAFMPF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
Sequence Annotation | METAL 446 446 Iron (heme axial ligand).
MOD_RES 138 138 Phosphoserine. |
Keyword | Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 504 AA |
Protein Sequence | MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL QVDLGNMPYS 60
LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED TADRPPVPIF EYLGVKPGSQ 120
GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM 180
LNKSTCNVIA SLIFARRFEY EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA 240
DKALQGQKSF IAILDNLLTE NRTTWDPVQA PRNLTDAFLA EIEKAKGNPE SSFNDENLLM 300
VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM ADQAHMPYTN 360
AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP NMSSMLKDES VWEKPLRFHP 420
EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA LARMELFLFF TCLLQRFSFS VPDGQPQPSN 480
SGVYGILVAP SPYQLCAVVR DQGH 504 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0070330; F:aromatase activity; IEA:EC. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |