UniProt Accession

 AHPC_MYCS2; A0R1V9; I7FIL4 

Genbank Protein ID

 CP000480; CP001663 

Genbank Nucleotide ID

 ABK73669.1; AFP41215.1 

Protein Name

 Alkyl hydroperoxide reductase subunit C 

Protein Synonyms/Alias

 Peroxiredoxin; Thioredoxin peroxidase 

Gene Name

 MSMEG_4891, MSMEI_4766 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 

NCBI Taxa ID

 246196 

Lysine Modification

Position	Peptide	Type	References
25	VVGGDLSKVDAKQPD	pupylation	[1]
29	DLSKVDAKQPDDYFT	pupylation	[1]
41	YFTRVTSKDYEGKWR	pupylation	[1, 2]

Reference

 [1] Proteome-wide identification of mycobacterial pupylation targets.
 Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH.
 Mol Syst Biol. 2010 Jul 13;6:386. [PMID: 20631680]
 [2] Expansion of the mycobacterial "PUPylome".
 Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC.
 Mol Biosyst. 2010 Feb;6(2):376-85. [PMID: 20094657] 

Functional Description

 Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in detoxification of isoniazid (By similarity). 

Sequence Annotation

 DOMAIN 4 170 Thioredoxin.
 ACT_SITE 61 61 Cysteine sulfenic acid (-SOH)
 DISULFID 61 61 Interchain (with C-174); in linked form
 DISULFID 174 174 Interchain (with C-61); in linked form
 CROSSLNK 41 41 Isoglutamyl lysine isopeptide (Lys-Gln)  

Keyword

 Antioxidant; Complete proteome; Disulfide bond; Isopeptide bond; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome; Stress response; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 195 AA 

Protein Sequence

Gene Ontology

 GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
 GO:0051920; F:peroxiredoxin activity; IEA:EC.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00578; AhpC-TSA 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS