CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034479
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Cald1 
Protein Synonyms/Alias
  
Gene Name
 Cald1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
113QEALERQKEFDPTITubiquitination[1]
284GGRASGDKEAEGAPQacetylation[2]
331ALELEELKKKREERRacetylation[2, 3]
367EEEKRRLKEEIERRRacetylation[4]
393EDGLSEDKKPFKCFTacetylation[4]
394DGLSEDKKPFKCFTPacetylation[2, 4]
397SEDKKPFKCFTPKGSacetylation[4]
407TPKGSSLKIEERAEFacetylation[4]
417ERAEFLNKSVQKSGVacetylation[2, 4]
417ERAEFLNKSVQKSGVsuccinylation[2]
417ERAEFLNKSVQKSGVubiquitination[1]
435HQAAVVSKIDSRLEQacetylation[4]
454IEGTKASKPMKPAASacetylation[4]
474AEGVRNIKSMWEKGSacetylation[2]
479NIKSMWEKGSVFSAPacetylation[4]
513RINEWLTKSPDGNKSacetylation[4]
542GKRNLWEKQSVDKVTacetylation[4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 554 AA 
Protein Sequence
MLSGSGSQGR RCLATLSQIA YQRNDDDEEE AARERRRRAR QERLRQKQEE ESLGQVTDQV 60
EAHVQNSVPD EESKPASSNT QVEGDEEAAL LERLARREER RQKRLQEALE RQKEFDPTIT 120
DGSLSGPSRR MQNDSAENET AEGEEKRESR SGRYEVEETE VVIKSYQKNS YQDAEDKKKE 180
EKEEEEQEKL KGGSLGENQE EEKGVKGQAQ RQKPRDDKPA FRKEEIKDEK IKKDKEPKEE 240
VKSFLDRKKG FTEVKAQNGE FMTHKLKQTE NAFSRSGGRA SGDKEAEGAP QVEAGKRLEE 300
LRRRRGETEN EEFEKLKQKQ QEAALELEEL KKKREERRKV LEEEEQRRKQ EEADRKAREE 360
EEKRRLKEEI ERRRAEAAEK RQKMPEDGLS EDKKPFKCFT PKGSSLKIEE RAEFLNKSVQ 420
KSGVRSTHQA AVVSKIDSRL EQYTNAIEGT KASKPMKPAA SDLPVPAEGV RNIKSMWEKG 480
SVFSAPSASG TPNKETAGLK VGVSSRINEW LTKSPDGNKS PAPKPSDLRP GDVSGKRNLW 540
EKQSVDKVTS PTKV 554 
Gene Ontology
 GO:0030478; C:actin cap; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0003779; F:actin binding; TAS:MGI.
 GO:0006936; P:muscle contraction; IEA:InterPro.
 GO:0006940; P:regulation of smooth muscle contraction; TAS:MGI. 
Interpro
 IPR006017; Caldesmon.
 IPR006018; Caldesmon_LSP. 
Pfam
 PF02029; Caldesmon 
SMART
  
PROSITE
  
PRINTS
 PR01076; CALDESMON.