CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002262
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine protease inhibitor A3K 
Protein Synonyms/Alias
 Serpin A3K; CPI-21; Contrapsin-like protease inhibitor 1; GHR-P63; Growth hormone-regulated proteinase inhibitor; Kallikrein-binding protein; KBP; SPI-2.3; Serine protease inhibitor 2; SPI-2; Thyroid hormone-regulated protein 
Gene Name
 Serpina3k 
Gene Synonyms/Alias
 Spin2b 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
331LPELGIRKIFSQQADacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. 
Sequence Annotation
 REGION 365 392 RCL.
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
 CARBOHYD 182 182 N-linked (GlcNAc...) (Potential).
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 267 267 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; Glycoprotein; Polymorphism; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 416 AA 
Protein Sequence
MAFIAALGLL MAGICPAVLC DGILGRDTLP HEDQGKGRQL HSLTLASINT DFTLSLYKKL 60
ALRNPDKNVV FSPLSISAAL AILSLGAKDS TMEEILEVLK FNLTEITEEE IHQGFGHLLQ 120
RLSQPEDQAE INTGSALFID KEQPILSEFQ EKTRALYQAE AFVADFKQCN EAKKFINDYV 180
SNQTQGKIAE LFSELDERTS MVLVNYLLFK GKWKVPFNPN DTFESEFYLD EKRSVKVPMM 240
KIKDLTTPYI RDEELSCSVL ELKYTGNASA LFILPDQGKM QQVESSLQPE TLKKWKDSLR 300
PRIISELRMP KFSISTDYNL EEVLPELGIR KIFSQQADLS RITGTKNLHV SQVVHKAVLD 360
VDETGTEGAA ATAVTAALKS LPQTIPLLNF NRPFMLVITD NNGQSVFFMG KVTNPM 416 
Gene Ontology
 GO:0005576; C:extracellular region; IBA:RefGenome.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 
Interpro
 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00284; SERPIN 
PRINTS