UniProt Accession

 BTF3_MOUSE; Q64152; Q64153; Q6GU63; Q6P3F3 

Genbank Protein ID

 BC008233; BC064010; BC080837; S79538; S79537 

Genbank Nucleotide ID

 AAH08233.1; AAH64010.1; AAH80837.1 

Protein Name

 Transcription factor BTF3 

Protein Synonyms/Alias

 RNA polymerase B transcription factor 3 

Gene Name

 Btf3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	ETIMNQEKLAKLQAQ	ubiquitination	[1]
55	MNQEKLAKLQAQVRI	acetylation	[2]
55	MNQEKLAKLQAQVRI	succinylation	[2]
55	MNQEKLAKLQAQVRI	ubiquitination	[1]
65	AQVRIGGKGTARRKK	acetylation	[2]
85	TATADDKKLQFSLKK	ubiquitination	[1]
91	KKLQFSLKKLGVNNI	ubiquitination	[1]
169	RLAEALPKQSVDGKA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity). 

Sequence Annotation

 DOMAIN 80 145 NAC-A/B.
 MOD_RES 30 30 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR002715; Nas_poly-pep-assoc_cplx_dom. 

Pfam

 PF01849; NAC 

SMART

  

PROSITE

 PS51151; NAC_AB 

PRINTS