UniProt Accession

 LAP2B_MOUSE; Q61029; Q3UCI5; Q61030; Q61031; Q61032 

Genbank Protein ID

 U39074; U39075; U39076; U39077; AK150305; AK150515; AK153281; AK165851; CH466539 

Genbank Nucleotide ID

 AAC52574.1; AAC52575.1; AAC52576.1; AAC52577.1; BAE29455.1; BAE29627.1; BAE31865.1; BAE38413.1; EDL21533.1 

Protein Name

 Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma 

Protein Synonyms/Alias

 Thymopoietin isoforms beta/delta/epsilon/gamma; TP beta/delta/epsilon/gamma 

Gene Name

 Tmpo 

Gene Synonyms/Alias

 Lap2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	VLTKDKLKSELVANN	acetylation	[1]
206	EPLKGRAKTPVTLKQ	acetylation	[2]
212	AKTPVTLKQRRTEHN	acetylation	[2]
212	AKTPVTLKQRRTEHN	ubiquitination	[3]
285	TPIAETIKASSNESL	ubiquitination	[3]
302	NRLTGNFKHASSILP	acetylation	[1, 2]
302	NRLTGNFKHASSILP	ubiquitination	[3]
333	TRAEVGEKTEERRVD	acetylation	[1]
333	TRAEVGEKTEERRVD	ubiquitination	[3]
388	MEESFSSKYVPKYAP	acetylation	[2]
388	MEESFSSKYVPKYAP	ubiquitination	[3]
392	FSSKYVPKYAPLADV	ubiquitination	[3]
400	YAPLADVKSEKTKKR	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity). 

Sequence Annotation

 DOMAIN 5 48 LEM-like.
 DOMAIN 109 153 LEM.
 REGION 1 409 Nucleoplasmic (Potential).
 REGION 49 108 Linker.
 REGION 137 242 NAKAP95-binding N.
 REGION 298 370 Binds lamins B.
 REGION 299 373 NAKAP95-binding C.
 MOD_RES 59 59 Phosphoserine (By similarity).
 MOD_RES 66 66 Phosphoserine.
 MOD_RES 67 67 Phosphoserine.
 MOD_RES 74 74 Phosphothreonine.
 MOD_RES 79 79 Phosphoserine (By similarity).
 MOD_RES 153 153 Phosphothreonine (By similarity).
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 159 159 Phosphothreonine.
 MOD_RES 163 163 Phosphothreonine (By similarity).
 MOD_RES 176 176 Phosphoserine.
 MOD_RES 179 179 Phosphoserine; by PKC.
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 207 207 Phosphothreonine.
 MOD_RES 210 210 Phosphothreonine (By similarity).
 MOD_RES 264 264 Phosphoserine (By similarity).
 MOD_RES 291 291 Phosphoserine (By similarity).
 MOD_RES 305 305 Phosphoserine (By similarity).
 MOD_RES 311 311 Phosphothreonine (By similarity).
 MOD_RES 314 314 Phosphoserine (By similarity).
 MOD_RES 361 361 Phosphoserine (By similarity).
 MOD_RES 384 384 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Membrane; Nucleus; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 452 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; ISO:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI. 

Interpro

 IPR013146; LEM-like_dom.
 IPR011015; LEM/LEM-like_dom.
 IPR003887; LEM_dom. 

Pfam

 PF03020; LEM
 PF08198; Thymopoietin 

SMART

 SM00540; LEM 

PROSITE

 PS50954; LEM
 PS50955; LEM_LIKE 

PRINTS