UniProt Accession

 SEC72_YEAST; P39742; D6VYT8 

Genbank Protein ID

 L29340; L07116; U17243; AY558214; L08690; BK006945 

Genbank Nucleotide ID

 AAA21840.1; AAB67338.1; AAS56540.1; DAA09604.1 

Protein Name

 Translocation protein SEC72 

Protein Synonyms/Alias

 Sec62/63 complex 23 kDa subunit; p23 

Gene Name

 SEC72 

Gene Synonyms/Alias

 SEC67; SIM2; YLR292C; L8003.18 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
175	ALAPEDMKLRALLIE	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Acts as non-essential component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC72 may be involved in signal peptide recognition for a defined subset of leader peptides, or may increase the efficiency of unusual or "difficult" secretory precursors to the translocation pore, it may be that this protein binds charged leader peptides to the membrane until they engage the translocation apparatus. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0031207; C:Sec62/Sec63 complex; IPI:SGD.
 GO:0008565; F:protein transporter activity; TAS:SGD.
 GO:0031204; P:posttranslational protein targeting to membrane, translocation; IDA:SGD. 

Interpro

 IPR001440; TPR-1.
 IPR011990; TPR-like_helical. 

Pfam

 PF00515; TPR_1 

SMART

  

PROSITE

  

PRINTS