UniProt Accession

 CISD2_MOUSE; Q9CQB5; Q9D0Y0 

Genbank Protein ID

 AM162549; AK003486; AK004257; AK005184; BC058279 

Genbank Nucleotide ID

 CAJ44265.1; BAB22814.1; BAB23237.1; BAB23868.1; AAH58279.1 

Protein Name

 CDGSH iron-sulfur domain-containing protein 2 

Protein Synonyms/Alias

 MitoNEET-related 1 protein; Miner1; Nervous system overexpressed protein 70 

Gene Name

 Cisd2 

Gene Synonyms/Alias

 Cdgsh2; Noxp70; Zcd2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
81	KIQKENPKVVNEINI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). 

Sequence Annotation

 METAL 99 99 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 101 101 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 110 110 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 114 114 Iron-sulfur (2Fe-2S); via pros nitrogen  

Keyword

 2Fe-2S; Autophagy; Complete proteome; Endoplasmic reticulum; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IMP:UniProtKB.
 GO:0010259; P:multicellular organismal aging; IMP:UniProtKB.
 GO:0010506; P:regulation of autophagy; IEA:Compara. 

Interpro

 IPR018967; FeS-contain_CDGSH-typ.
 IPR006622; FeS-contain_CDGSH-typ_subfam.
 IPR019610; FeS-contain_mitoNEET_N. 

Pfam

 PF10660; MitoNEET_N
 PF09360; zf-CDGSH 

SMART

 SM00704; ZnF_CDGSH 

PROSITE

  

PRINTS