| Tag | Content |
|---|
| CPLM ID | CPLM-015230 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FK506-binding protein 15 |
Protein Synonyms/Alias | FKBP-15; 133 kDa FK506-binding protein; 133 kDa FKBP; FKBP-133; WASP and FKBP-like; WAFL |
Gene Name | Fkbp15 |
Gene Synonyms/Alias | Fkbp133; Kiaa0674 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 359 | NSNPDTVKAKLISRM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement (By similarity). May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase. |
Sequence Annotation | DOMAIN 196 289 PPIase FKBP-type.
REGION 71 168 Important for function in growth cone
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 14 14 Phosphoserine (By similarity).
MOD_RES 91 91 N6-acetyllysine (By similarity).
MOD_RES 306 306 Phosphoserine.
MOD_RES 340 340 Phosphoserine.
MOD_RES 344 344 Phosphoserine (By similarity).
MOD_RES 948 948 Phosphoserine (By similarity).
MOD_RES 1091 1091 Phosphoserine.
MOD_RES 1093 1093 Phosphothreonine.
MOD_RES 1108 1108 Phosphoserine (By similarity).
MOD_RES 1157 1157 Phosphoserine.
MOD_RES 1159 1159 Phosphoserine.
MOD_RES 1190 1190 Phosphoserine.
MOD_RES 1198 1198 Phosphothreonine (By similarity). |
Keyword | Acetylation; Actin-binding; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Endosome; Phosphoprotein; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1216 AA |
Protein Sequence | MFGAGDEDDT DFLSPSGGAK LASLFGLDQA TMGHGNEFFQ YTAPKQPKKG QGTAAGNQTA 60
PKPAPATTGT SSVLFATAVH AYRYINGQYA KQGKFGAAVL GNHTSREYRI LLYISQQQPV 120
TVATIHLNFE LMVRPNNYST FYDDQRQNWS IMFESEKAAV SFNKQVCVAK CNSISSLDAV 180
LCQDLVAAEG PAVETGDSLE VAYTGWLLQN HVLGQVFDST ANKDKPLRLK LGSGKVVKGL 240
EDGLLGMKKG GKRLIITPSA CAAGSEGVIG WTQPTDSILV FEVEVRRVKF ARDSGSDGHS 300
VSSRDSAAPS PIPASDSLSA DPVVTPLPLP LKPGEPGLRS KSNSLSEQLT VNSNPDTVKA 360
KLISRMAKMG QPMLPILPPQ LDSNDSETED ATVLRGAGQS LVTPSIQPSL QPAHPVLPQM 420
ASQAPQPSGS GLQTPSAALM QAVSLDSHSA VSGNAQNFQP YAGVQAYAYP QTPSVTSQLQ 480
PVRPLYPAPL SQAPHFQGSG DMMSFLMTEA RQHNTEIRMA VNKVADKMDH LMTKVEELQK 540
HSSGNSMLLP SMSVTMETSM IMSNIQRIIQ ENERLKQELL EKSSRIEEQN DKISDLIERN 600
QRYVEQSNLM MEKRNNSLQT ATENTQARIL HAEQEKAKVT EELAAATAQV SHLQLKMTAH 660
QKKETELQLQ LTDNLKETDL LRGHVTRLQA DLSELREASE QTQTKFKSEK QSRRQLELKV 720
TSLEEELTDL RAEKTSLEKN LSERKKKSAQ ERCQAEAEMD EIRKSHQEEL DRLRQLLKKA 780
RVSTDQAAAE QLTLAQAELQ SQWEAKCEQL LASARDEHLQ QYREVCAQRD AHQQKLALLQ 840
DECLALQAQI AAFTEQKEHM QRLEKTKSQA PAGRAAADPS EKVKKIMNQV FQSLRGEFEL 900
EESYDGGTIL RTIMHTIKMV TLQLLNHQEE EEEEEEEEEE EKKPLRPSLE QPGPATPGMP 960
PAPPSGETQE APEVLPEQVV GETTPLPLQA LPTPENGAQT RKGEPAEAEV PSEIKDSSLP 1020
PQPAGIPAHR VLGPPTSIPP KPPGPVTMDS ESEEMLAADQ RTVQPNGLLG EEHVREVATD 1080
GLLQGNSRRL SLTPDPEKGE PPALDPESQG GEAQPPECKQ AEDVSSSGPR ETLLDTELAS 1140
AAAGTSLRHN QDSQHCSLSG DEEDELFKGA TLKVPRPTAQ PEEEDEDEVS MKGRPPPTPL 1200
FGDDDDDDDD DIGWLG 1216 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |