UniProt Accession

 RU1C_MOUSE; Q62241 

Genbank Protein ID

 X96767; U70315; BC008243 

Genbank Nucleotide ID

 CAA65542.1; AAB08894.1; AAH08243.1 

Protein Name

 U1 small nuclear ribonucleoprotein C 

Protein Synonyms/Alias

 U1 snRNP C; U1-C; U1C 

Gene Name

 Snrpc 

Gene Synonyms/Alias

 Snrp1c 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MPKFYCDYCD	acetylation	[1]
52	QAQSLIDKTTAAFQQ	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). 

Sequence Annotation

 ZN_FING 4 36 Matrin-type.
 MOD_RES 8 8 Phosphotyrosine (By similarity).
 MOD_RES 17 17 Phosphoserine (By similarity).
 MOD_RES 52 52 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:Compara.
 GO:0000243; C:commitment complex; IEA:HAMAP.
 GO:0005685; C:U1 snRNP; IEA:HAMAP.
 GO:0071004; C:U2-type prespliceosome; IEA:HAMAP.
 GO:0003729; F:mRNA binding; IEA:HAMAP.
 GO:0003727; F:single-stranded RNA binding; IEA:Compara.
 GO:0030619; F:U1 snRNA binding; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0000395; P:mRNA 5'-splice site recognition; IEA:HAMAP.
 GO:0000387; P:spliceosomal snRNP assembly; IEA:HAMAP. 

Interpro

 IPR017340; U1_snRNP-C.
 IPR000690; Znf_C2H2_matrin.
 IPR003604; Znf_U1.
 IPR013085; Znf_U1-C. 

Pfam

 PF06220; zf-U1 

SMART

 SM00451; ZnF_U1 

PROSITE

 PS50171; ZF_MATRIN 

PRINTS