UniProt Accession

 HNRH2_MOUSE; P70333; Q3THV9 

Genbank Protein ID

 U58105; AK077716; AK164115; AK168116; AK169104; BC005461 

Genbank Nucleotide ID

 AAB47243.1; BAC36976.1; BAE37634.1; BAE40087.1; BAE40886.1; AAH05461.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein H2 

Protein Synonyms/Alias

 hnRNP H2; Heterogeneous nuclear ribonucleoprotein H'; hnRNP H'; Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed 

Gene Name

 Hnrnph2 

Gene Synonyms/Alias

 Hnrph2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
35	MRFFSDCKIQNGTSG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity). 

Sequence Annotation

 DOMAIN 11 90 RRM 1.
 DOMAIN 111 188 RRM 2.
 REPEAT 234 249 1-1.
 DOMAIN 289 364 RRM 3.
 REPEAT 354 372 2-1.
 REPEAT 374 392 2-2.
 REPEAT 418 433 1-2.
 REGION 234 433 2 X 16 AA Gly-rich approximate repeats.
 REGION 354 392 2 X 19 AA perfect repeats.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylmethionine; in Heterogeneous
 MOD_RES 23 23 Phosphoserine (By similarity).
 MOD_RES 63 63 Phosphoserine (By similarity).
 MOD_RES 104 104 Phosphoserine.
 MOD_RES 107 107 Phosphothreonine.
 MOD_RES 233 233 Dimethylated arginine; alternate (By
 MOD_RES 233 233 Omega-N-methylarginine; alternate (By
 MOD_RES 246 246 Phosphotyrosine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 449 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; ISO:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR012996; Znf_CHHC. 

Pfam

 PF08080; zf-RNPHF 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS