CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031089
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sarcosine dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 cDNA FLJ54446, highly similar to Sarcosine dehydrogenase, mitochondrial (EC 1.5.99.1); cDNA, FLJ79393, highly similar to Sarcosine dehydrogenase, mitochondrial (EC 1.5.99.1) 
Gene Name
 SARDH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
410FDMSYFGKFYLVGLDubiquitination[1]
420LVGLDARKAADWLFSubiquitination[1]
589AVMAAGAKHGLINAGubiquitination[1, 2]
607IDSLSIEKGYRHWHAubiquitination[1, 2]
632AGLAFTCKLKSPVPFubiquitination[1]
634LAFTCKLKSPVPFLGubiquitination[1]
716PVSLDFVKSGDYALEubiquitination[1, 2]
744SPFDPNNKRVKGIY*ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 750 AA 
Protein Sequence
MSLGKAYGVE SHVLSPAETK TLYPLMNVDD LYGTLYVPHD GTMDPAGTCT TLARAASARG 60
AQVIENCPVT GIRVWTDDFG VRRVAGVETQ HGSIQTPCVV NCAGVWASAV GRMAGVKVPL 120
VAMHHAYVVT ERIEGIQNMP NVRDHDASVY LRLQGDALSV GGYEANPIFW EEVSDKFAFG 180
LFDLDWEVFT QHIEGAINRV PVLEKTGIKS TVCGPESFTP DHKPLMGEAP ELRGFFLGCG 240
FNSAGMMLGG GCGQELAHWI IHGRPEKDMH GYDIRRFHHS LTDHPRWIRE RSHESYAKNY 300
SVVFPHDEPL AGRNMRRDPL HEELLGQGCV FQERHGWERP GWFHPRGPAP VLEYDYYGAY 360
GSRAHEDYAY RRLLADEYTF AFPPHHDTIK KECLACRGAA AVFDMSYFGK FYLVGLDARK 420
AADWLFSADV SRPPGSTVYT CMLNHRGGTE SDLTVSRLAP SHQASPLAPA FEGDGYYLAM 480
GGAVAQHNWS HITTVLQDQK SQCQLIDSSE DLGMISIQGP ASRAILQEVL DADLSNEAFP 540
FSTHKLLRAA GHLVRAMRLS FVGELGWELH IPKASCVPVY RAVMAAGAKH GLINAGYRAI 600
DSLSIEKGYR HWHADLRPDD SPLEAGLAFT CKLKSPVPFL GREALEQQRA AGLRRRLVCF 660
TMEDKVPMFG LEAIWRNGQV VGHVRRADFG FAIDKTIAYG YIHDPSGGPV SLDFVKSGDY 720
ALERMGVTYG AQAHLKSPFD PNNKRVKGIY 750 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0006546; P:glycine catabolic process; IEA:InterPro. 
Interpro
 IPR006076; FAD-dep_OxRdtase.
 IPR013977; GCV_T_C.
 IPR006222; GCV_T_N.
 IPR027266; TrmE/GcvT_dom1. 
Pfam
 PF01266; DAO
 PF01571; GCV_T
 PF08669; GCV_T_C 
SMART
  
PROSITE
  
PRINTS