UniProt Accession

 SIKE1_HUMAN; Q9BRV8; Q5TEZ7; Q5TEZ9; Q68DZ4; Q9H778 

Genbank Protein ID

 AK024821; CR749219; AL096773; AL096773; AL096773; CH471122; BC005934 

Genbank Nucleotide ID

 BAB15020.1; CAH18076.1; CAI18822.1; CAI18823.1; CAI18824.1; EAW56620.1; AAH05934.1 

Protein Name

 Suppressor of IKBKE 1 

Protein Synonyms/Alias

 Suppressor of IKK-epsilon 

Gene Name

 SIKE1 

Gene Synonyms/Alias

 SIKE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	EKILTDAKTLLERLR	ubiquitination	[1, 2]
62	QEDASDMKDMSKYKP	ubiquitination	[1, 3]
120	LQLMVAKKAVDAEPV	ubiquitination	[1]
154	EMGEVMRKAVQVDDD	ubiquitination	[1, 2]
165	VDDDQFCKIQEKLAQ	ubiquitination	[1]
169	QFCKIQEKLAQLELE	ubiquitination	[1, 3]
178	AQLELENKELRELLS	ubiquitination	[1]
195	SESLQARKENSMDTA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. 

Sequence Annotation

  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 207 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0045087; P:innate immune response; TAS:Reactome. 

Interpro

 IPR008555; SIKE. 

Pfam

 PF05769; DUF837 

SMART

  

PROSITE

  

PRINTS