UniProt Accession

 SUCA_RAT; P13086; Q6P7S4 

Genbank Protein ID

 BC061537; J03621 

Genbank Nucleotide ID

 AAH61537.2; AAA41233.1 

Protein Name

 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 

Protein Synonyms/Alias

 Succinyl-CoA synthetase subunit alpha; SCS-alpha 

Gene Name

 Suclg1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
48	GSYTASRKNIYIDKN	acetylation	[1]
54	RKNIYIDKNTKVICQ	acetylation	[1]
57	IYIDKNTKVICQGFT	acetylation	[1]
66	ICQGFTGKQGTFHSQ	acetylation	[1]
81	QALEYGTKLVGGTTP	acetylation	[1]
90	VGGTTPGKGGKKHLG	acetylation	[1]
105	LPVFNTVKEAKEKTG	acetylation	[1]
108	FNTVKEAKEKTGATA	acetylation	[1]
156	QQDMVRVKHKLTRQG	acetylation	[1]
192	IMPGHIHKKGRIGIV	acetylation	[1]
271	ENAAEFLKEHNSGPK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity). 

Sequence Annotation

 ACT_SITE 299 299 Tele-phosphohistidine intermediate.
 MOD_RES 54 54 N6-acetyllysine (By similarity).
 CROSSLNK 280 280 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Complete proteome; GTP-binding; Isopeptide bond; Ligase; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide; Tricarboxylic acid cycle; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0045244; C:succinate-CoA ligase complex (GDP-forming); IDA:RGD.
 GO:0003878; F:ATP citrate synthase activity; IEA:InterPro.
 GO:0048037; F:cofactor binding; IEA:InterPro.
 GO:0019003; F:GDP binding; IDA:RGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; IDA:RGD.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IDA:RGD.
 GO:0004776; F:succinate-CoA ligase (GDP-forming) activity; IDA:RGD.
 GO:0006105; P:succinate metabolic process; IDA:RGD.
 GO:0006104; P:succinyl-CoA metabolic process; IDA:RGD.
 GO:0006099; P:tricarboxylic acid cycle; IDA:RGD. 

Interpro

 IPR017440; Cit_synth/succinyl-CoA_lig_AS.
 IPR003781; CoA-bd.
 IPR005810; CoA_lig_alpha.
 IPR005811; CoA_ligase.
 IPR016040; NAD(P)-bd_dom.
 IPR016102; Succinyl-CoA_synth-like. 

Pfam

 PF02629; CoA_binding
 PF00549; Ligase_CoA 

SMART

 SM00881; CoA_binding 

PROSITE

 PS01216; SUCCINYL_COA_LIG_1
 PS00399; SUCCINYL_COA_LIG_2 

PRINTS

 PR01798; SCOASYNTHASE.