UniProt Accession

 EXOS4_HUMAN; Q9NPD3 

Genbank Protein ID

 AF281133; AK000598; AC109322; BC002777 

Genbank Nucleotide ID

 AAF82134.1; BAA91279.1; AAH02777.1 

Protein Name

 Exosome complex component RRP41 

Protein Synonyms/Alias

 Exosome component 4; Ribosomal RNA-processing protein 41; p12A 

Gene Name

 EXOSC4 

Gene Synonyms/Alias

 RRP41; SKI6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
95	RRPHGDRKSCEMGLQ	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Exosome; Nucleus; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000178; C:exosome (RNase complex); IDA:UniProtKB.
 GO:0005730; C:nucleolus; NAS:UniProtKB.
 GO:0035327; C:transcriptionally active chromatin; IMP:UniProtKB.
 GO:0000175; F:3'-5'-exoribonuclease activity; NAS:UniProtKB.
 GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
 GO:0051607; P:defense response to virus; IMP:MGI.
 GO:0045006; P:DNA deamination; IDA:UniProtKB.
 GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome.
 GO:0071044; P:histone mRNA catabolic process; IMP:UniProtKB.
 GO:0000460; P:maturation of 5.8S rRNA; IMP:UniProtKB.
 GO:0071028; P:nuclear mRNA surveillance; IMP:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB. 

Interpro

 IPR001247; ExoRNase_PH_dom1.
 IPR015847; ExoRNase_PH_dom2.
 IPR027408; PNPase/RNase_PH_dom.
 IPR020568; Ribosomal_S5_D2-typ_fold. 

Pfam

 PF01138; RNase_PH
 PF03725; RNase_PH_C 

SMART

  

PROSITE

  

PRINTS