CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037047
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 N-acetyltransferase 10 
Protein Synonyms/Alias
  
Gene Name
 NAT10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
167DLELRELKESLQDTQubiquitination[1]
184GVLVDCCKTLDQAKAubiquitination[1]
190CKTLDQAKAVLKFIEubiquitination[1, 2]
194DQAKAVLKFIEGISEubiquitination[1]
202FIEGISEKTLRSTVAubiquitination[1, 2, 3]
354TGRSLSLKLIQQLRQacetylation[2, 4, 5]
354TGRSLSLKLIQQLRQubiquitination[1]
375VSTTAENKTTTTARLubiquitination[1, 2, 3, 6, 7]
448DTLFCYHKASEVFLQubiquitination[1, 2]
527NSLSRGKKASGDLIPubiquitination[1]
751LFLPYDLKRLEMYSRubiquitination[1, 2, 3]
832RIIRKVVKLFNEVQEacetylation[4]
832RIIRKVVKLFNEVQEubiquitination[8]
870DDLDEAAKEFQEKHKubiquitination[1]
917NASIISLKSDKKRKLubiquitination[1, 2]
931LEAKQEPKQSKKLKNubiquitination[7]
934KQEPKQSKKLKNRETubiquitination[7]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [8] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 953 AA 
Protein Sequence
MRQLQKKIKN GTLNIKQDDP FELFIAATNI RYCYYNETHK ILGNTFGMCV LQDFEALTPN 60
LLARTVETVE GGGLVVILLR TMNSLKQLYT VTMDVHSRYR TEAHQDVVGR FNERFILSLA 120
SCKKCLVIDD QLNILPISSH VATMEALPPQ TPDESLGPSD LELRELKESL QDTQPVGVLV 180
DCCKTLDQAK AVLKFIEGIS EKTLRSTVAL TAARGRGKSA ALGLAIAGAV AFGYSNIFVT 240
SPSPDNLHTL FEFVFKGFDA LQYQEHLDYE IIQSLNPEFN KAVIRVNVFR EHRQTIQYIH 300
PADAVKLGQA ELVVIDEAAA IPLPLVKSLL GPYLVFMAST INGYEGTGRS LSLKLIQQLR 360
QQSAQSQVST TAENKTTTTA RLASARTLYE VSLQESIRYA PGDAVEKWLN DLLCLDCLNI 420
TRIVSGCPLP EACELYYVNR DTLFCYHKAS EVFLQRLMAL YVASHYKNSP NDLQMLSDAP 480
AHHLFCLLPP VPPTQNALPE VLAVIQVCLE GEISRQSILN SLSRGKKASG DLIPWTVSEQ 540
FQDPDFGGLS GGRVVRIAVH PDYQGMGYGS RALQLLQMYY EGRFPCLEEK VLETPQEIHT 600
VSSEAVSLLE EVITPRKDLP PLLLKLNERP AERLDYLGVS YGLTPRLLKF WKRAGFVPVY 660
LRQTPNDLTG EHSCIMLKTL TDEDEADQGG WLAAFWKDFR RRFLALLSYQ FSTFSPSLAL 720
NIIQNRNMGK PAQPALSREE LEALFLPYDL KRLEMYSRNM VDYHLIMDMI PAISRIYFLN 780
QLGDLALSAA QSALLLGIGL QHKSVDQLEK EIELPSGQLM GLFNRIIRKV VKLFNEVQEK 840
AIEEQMVAAK DVVMEPTMKT LSDDLDEAAK EFQEKHKKEV GKLKSMDLSE YIIRGDDEEW 900
NEVLNKAGPN ASIISLKSDK KRKLEAKQEP KQSKKLKNRE TKNKKDMKLK RKK 953 
Gene Ontology
 GO:0008080; F:N-acetyltransferase activity; IEA:InterPro. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR013562; DUF1726.
 IPR000182; GNAT_dom.
 IPR007807; Helicase_dom. 
Pfam
 PF08351; DUF1726
 PF05127; Helicase_RecD 
SMART
  
PROSITE
 PS51186; GNAT 
PRINTS