CPLM-018067

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018067

UniProt Accession

DEN1A_HUMAN; Q8TEH3; A8MZA3; B1AM80; B7Z3C8; B7Z669; D3PFD3; Q05C88; Q5VWF0; Q6PJZ5; Q8IVD6; Q9H796

Genbank Protein ID

AK024782; AK074151; AK295710; AK299867; AL445489; AL161790; AL390774; AC006450; AL445489; AC006450; AL390774; AL161790; AL390774; AC006450; AL161790; AL445489; AL161790; AC006450; AL445489; AL390774; AL161790; AC006450; AL390774; AL445489; AL161790; AC006450; AL390774; AL445489; AL390774; AC006450; AL445489; AL161790; AL390774; AC006450; AL445489; AL161790; AL445489; AC006450; AL161790; AL390774; CH471090; CH471090; BC009616; BC028061; BC039703; BK006958

Genbank Nucleotide ID

BAB15002.1; BAB84977.1; BAH12164.1; BAH13155.1; CAI39791.1; CAI39791.1; CAI39791.1; CAI39791.1; CAI39792.1; CAI39792.1; CAI39792.1; CAI39792.1; CAH73640.1; CAH73640.1; CAH73640.1; CAH73640.1; CAI15705.1; CAI15705.1; CAI15705.1; CAI15705.1; CAI15706.1; CAI15706.1; CAI15706.1; CAI15706.1; CAI15707.1; CAI15707.1; CAI15707.1; CAI15707.1; CAH73637.1; CAH73637.1; CAH73637.1; CAH73637.1; CAH73638.1; CAH73638.1; CAH73638.1; CAH73638.1; CAI39794.1; CAI39794.1; CAI39794.1; CAI39794.1; EAW87571.1; EAW87575.1; AAH09616.1; AAH28061.1; AAH39703.1; DAA12500.1

Protein Name

DENN domain-containing protein 1A

Protein Synonyms/Alias

Connecdenn 1; Connecdenn; Protein FAM31A

Gene Name

DENND1A

Gene Synonyms/Alias

FAM31A; KIAA1608

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
267	SLKNRLKKVSTTTGD	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles.

Sequence Annotation

DOMAIN 24 91 UDENN.
DOMAIN 92 273 DENN.
DOMAIN 304 371 dDENN.
MOD_RES 519 519 Phosphothreonine.
MOD_RES 520 520 Phosphoserine.
MOD_RES 523 523 Phosphoserine.
MOD_RES 536 536 Phosphoserine.
MOD_RES 538 538 Phosphoserine.
MOD_RES 546 546 Phosphoserine.
MOD_RES 592 592 Phosphoserine.

Keyword

Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasmic vesicle; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Protein transport; Reference proteome; Synapse; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1009 AA

Protein Sequence

MRRPGDHGLQ DQEVLQTLTK FCFPFYVDSL TVSQVGQNFT FVLTDIDSKQ RFGFCRLSSG 60
AKSCFCILSY LPWFEVFYKL LNILADYTTK RQENQWNELL ETLHKLPIPD PGVSVHLSVH 120
SYFTVPDTRE LPSIPENRNL TEYFVAVDVN NMLHLYASML YERRILIICS KLSTLTACIH 180
GSAAMLYPMY WQHVYIPVLP PHLLDYCCAP MPYLIGIHLS LMEKVRNMAL DDVVILNVDT 240
NTLETPFDDL QSLPNDVISS LKNRLKKVST TTGDGVARAF LKAQAAFFGS YRNALKIEPE 300
EPITFCEEAF VSHYRSGAMR QFLQNATQLQ LFKQFIDGRL DLLNSGEGFS DVFEEEINMG 360
EYAGSDKLYH QWLSTVRKGS GAILNTVKTK ANPAMKTVYK FAKDHAKMGI KEVKNRLKQK 420
DIAENGCAPT PEEQLPKTAP SPLVEAKDPK LREDRRPITV HFGQVRPPRP HVVKRPKSNI 480
AVEGRRTSVP SPEHLVKPLR HYAVFLSEDS SDDECQREEG PSSGFTESFF FSAPFEWPQP 540
YRTLRESDSA EGDEAESPEQ QVRKSTGPVP APPDRAASID LLEDVFSNLD MEAALQPLGQ 600
AKSLEDLRAP KDLREQPGTF DYQRLDLGGS ERSRGVTVAL KLTHPYNKLW SLGQDDMAIP 660
SKPPAASPEK PSALLGNSLA LPRRPQNRDS ILNPSDKEEV PTPTLGSITI PRPQGRKTPE 720
LGIVPPPPIP RPAKLQAAGA ALGDVSERLQ TDRDRRAALS PGLLPGVVPQ GPTELLQPLS 780
PGPGAAGTSS DALLALLDPL STAWSGSTLP SRPATPNVAT PFTPQFSFPP AGTPTPFPQP 840
PLNPFVPSMP AAPPTLPLVS TPAGPFGAPP ASLGPAFASG LLLSSAGFCA PHRSQPNLSA 900
LSMPNLFGQM PMGTHTSPLQ PLGPPAVAPS RIRTLPLARS SARAAETKQG LALRPGDPPL 960
LPPRPPQGLE PTLQPSAPQQ ARDPFEDLLQ KTKQDVSPSP ALAPAPDSVE QLRKQWETFE 1020

Gene Ontology

GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.
GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
GO:0030425; C:dendrite; IEA:Compara.
GO:0043025; C:neuronal cell body; IEA:Compara.
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0006897; P:endocytosis; IMP:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:0048488; P:synaptic vesicle endocytosis; IEA:Compara.

Interpro

IPR005112; dDENN_dom.
IPR001194; DENN_dom.
IPR005113; uDENN_dom.

Pfam

PF03455; dDENN
PF02141; DENN
PF03456; uDENN

SMART

SM00801; dDENN
SM00799; DENN
SM00800; uDENN

PROSITE

PS50947; DDENN
PS50211; DENN
PS50946; UDENN

PRINTS