UniProt Accession

 CTNA1_HUMAN; P35221; Q12795 

Genbank Protein ID

 D14705; D13866; L23805; U03100; AF102803; AF102787; AF102788; AF102789; AF102790; AF102791; AF102792; AF102793; AF102794; AF102795; AF102796; AF102797; AF102798; AF102799; AF102800; AF102801; AF102802; AY884207; BC000385; L22080 

Genbank Nucleotide ID

 BAA03530.1; BAA02979.1; AAA86430.1; AAA18949.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAC99459.1; AAW56940.1; AAH00385.1; AAA35502.1 

Protein Name

 Catenin alpha-1 

Protein Synonyms/Alias

 Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13 

Gene Name

 CTNNA1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	HAGNINFKWDPKSLE	ubiquitination	[1, 2]
16	INFKWDPKSLEIRTL	ubiquitination	[1, 2]
45	TLVNTNSKGPSNKKR	ubiquitination	[2, 3]
81	EKGDKIAKESQFLKE	ubiquitination	[1]
163	VVEDGILKLRNAGNE	ubiquitination	[1]
178	QDLGIQYKALKPEVD	ubiquitination	[1, 3]
181	GIQYKALKPEVDKLN	ubiquitination	[3]
478	LAAKPQSKLAQENMD	ubiquitination	[1, 3]
571	EPGVYTEKVLEATKL	ubiquitination	[3]
577	EKVLEATKLLSNTVM	ubiquitination	[1]
683	LPQEQKAKIAEQVAS	ubiquitination	[3]
695	VASFQEEKSKLDAEV	ubiquitination	[3]
925	VQALSEFKAMDSI**	ubiquitination	[3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. 

Sequence Annotation

 REGION 2 228 Involved in homodimerization.
 REGION 97 148 Interaction with JUP and CTNNB1.
 REGION 325 394 Interaction with alpha-actinin.
 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 634 634 Phosphothreonine.
 MOD_RES 641 641 Phosphoserine.
 MOD_RES 645 645 Phosphothreonine.
 MOD_RES 652 652 Phosphoserine.
 MOD_RES 654 654 Phosphothreonine (By similarity).
 MOD_RES 655 655 Phosphoserine (By similarity).
 MOD_RES 658 658 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 906 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0016342; C:catenin complex; IDA:BHF-UCL.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005915; C:zonula adherens; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0007568; P:aging; IEA:Compara.
 GO:0043297; P:apical junction assembly; NAS:UniProtKB.
 GO:0031103; P:axon regeneration; IEA:Compara.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0071681; P:cellular response to indole-3-methanol; IDA:UniProtKB.
 GO:0007163; P:establishment or maintenance of cell polarity; IEA:Compara.
 GO:0016264; P:gap junction assembly; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0042692; P:muscle cell differentiation; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0007406; P:negative regulation of neuroblast proliferation; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome.
 GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara. 

Interpro

 IPR001033; Alpha_catenin.
 IPR006077; Vinculin/catenin.
 IPR000633; Vinculin_CS. 

Pfam

 PF01044; Vinculin 

SMART

  

PROSITE

 PS00663; VINCULIN_1 

PRINTS

 PR00805; ALPHACATENIN.