CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004597
UniProt Accession
Genbank Protein ID
 M26209 
Genbank Nucleotide ID
Protein Name
 Erythroid transcription factor 
Protein Synonyms/Alias
 Eryf1; GATA-binding factor 1; GATA-1; NF-E1 DNA-binding protein; NF-E1a 
Gene Name
 GATA1 
Gene Synonyms/Alias
 ERYF1 
Created Date
 July 27, 2013 
Organism
 Gallus gallus (Chicken) 
NCBI Taxa ID
 9031 
Lysine Modification
Position
Peptide
Type
References
158KKRLLVSKRAGTVCSacetylation[1]
193NACGLYYKLHQVNRPacetylation[1]
205NRPLTMRKDGIQTRNacetylation[1]
214GIQTRNRKVSSKGKKacetylation[1]
218RNRKVSSKGKKRRPPacetylation[1]
220RKVSSKGKKRRPPGGacetylation[1]
221KVSSKGKKRRPPGGGacetylation[1]
Reference
 [1] Regulation of activity of the transcription factor GATA-1 by acetylation.
 Boyes J, Byfield P, Nakatani Y, Ogryzko V.
 Nature. 1998 Dec 10;396(6711):594-8. [PMID: 9859997] 
Functional Description
 Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. 
Sequence Annotation
 ZN_FING 110 134 GATA-type 1.
 ZN_FING 164 188 GATA-type 2.
 MOD_RES 151 151 N6-acetyllysine; by EP300 (Probable).
 MOD_RES 152 152 N6-acetyllysine; by EP300 (Probable).
 MOD_RES 158 158 N6-acetyllysine; by EP300.
 MOD_RES 214 214 N6-acetyllysine; by EP300.
 MOD_RES 218 218 N6-acetyllysine; by EP300.
 MOD_RES 220 220 N6-acetyllysine; by EP300.  
Keyword
 3D-structure; Acetylation; Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 304 AA 
Protein Sequence
MEFVALGGPD AGSPTPFPDE AGAFLGLGGG ERTEAGGLLA SYPPSGRVSL VPWADTGTLG 60
TPQWVPPATQ MEPPHYLELL QPPRGSPPHP SSGPLLPLSS GPPPCEAREC VNCGATATPL 120
WRRDGTGHYL CNACGLYHRL NGQNRPLIRP KKRLLVSKRA GTVCSNCQTS TTTLWRRSPM 180
GDPVCNACGL YYKLHQVNRP LTMRKDGIQT RNRKVSSKGK KRRPPGGGNP SATAGGGAPM 240
GGGGDPSMPP PPPPPAAAPP QSDALYALGP VVLSGHFLPF GNSGGFFGGG AGGYTAPPGL 300
SPQI 304 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000679; Znf_GATA.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00320; GATA 
SMART
 SM00401; ZnF_GATA 
PROSITE
 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2 
PRINTS
 PR00619; GATAZNFINGER.