UniProt Accession

 IL26_HUMAN; Q9NPH9 

Genbank Protein ID

 AJ251550; AJ251551; AJ251549; AY509906; BC066270; BC066271 

Genbank Nucleotide ID

 CAB77049.1; CAB77049.1; CAB76942.1; AAR87776.1; AAH66270.1; AAH66271.1 

Protein Name

 Interleukin-26 

Protein Synonyms/Alias

 IL-26; Protein AK155 

Gene Name

 IL26 

Gene Synonyms/Alias

 AK155 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	TIPEDRIKNIRLLKK	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytokine; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005125; F:cytokine activity; IDA:UniProtKB.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IDA:UniProtKB.
 GO:0050715; P:positive regulation of cytokine secretion; IDA:UniProtKB.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
 GO:0046427; P:positive regulation of JAK-STAT cascade; IDA:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:UniProtKB.
 GO:0032874; P:positive regulation of stress-activated MAPK cascade; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. 

Interpro

 IPR009079; 4_helix_cytokine-like_core.
 IPR012351; 4_helix_cytokine_core.
 IPR020443; Interleukin-10/19/20/24.
 IPR020423; Interleukin-10_CS. 

Pfam

 PF00726; IL10 

SMART

 SM00188; IL10 

PROSITE

 PS00520; INTERLEUKIN_10 

PRINTS