UniProt Accession

 H2A4_CHICK; P02263 

Genbank Protein ID

 D11055; V00413; X02218 

Genbank Nucleotide ID

 BAA01798.1; CAA23704.1; CAA26139.1 

Protein Name

 Histone H2A-IV 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Gallus gallus (Chicken) 

NCBI Taxa ID

 9031 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKQGGKARA	acetylation	[1]
10	GRGKQGGKARAKAKS	acetylation	[2]

Reference

 [1] Free-flow electrophoresis for top-down proteomics by Fourier transform ion cyclotron resonance mass spectrometry.
 Ouvry-Patat SA, Torres MP, Quek HH, Gelfand CA, O'Mullan P, Nissum M, Schroeder GK, Han J, Elliott M, Dryhurst D, Ausio J, Wolfenden R, Borchers CH.
 Proteomics. 2008 Jul;8(14):2798-808. [PMID: 18655049]
 [2] Analysis of core histones by liquid chromatography-mass spectrometry and peptide mapping.
 Zhang K, Tang H.
 J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 5;783(1):173-9. [PMID: 12450536] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 10 10 N6-acetyllysine.
 CROSSLNK 14 14 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 16 16 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 120 120 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 129 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.