UniProt Accession

 PPIL3_HUMAN; Q9H2H8; Q86WF9; Q96IA9; Q9BXZ1 

Genbank Protein ID

 AF251049; AF271652; AF146799; AK027315; AC005037; BC007693 

Genbank Nucleotide ID

 AAK34939.1; AAG44766.1; AAO64723.1; BAB55036.1; AAY14723.1; AAH07693.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase-like 3 

Protein Synonyms/Alias

 PPIase; Cyclophilin J; CyPJ; Cyclophilin-like protein PPIL3; Rotamase PPIL3 

Gene Name

 PPIL3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	CIFHRNIKGFMVQTG	ubiquitination	[1]
133	ETLDELEKLPVNEKT	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. 

Sequence Annotation

 DOMAIN 1 154 PPIase cyclophilin-type.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Isomerase; mRNA processing; mRNA splicing; Polymorphism; Reference proteome; Rotamase; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR024936; Cyclophilin-type_PPIase.
 IPR020892; Cyclophilin-type_PPIase_CS. 

Pfam

 PF00160; Pro_isomerase 

SMART

  

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 

PRINTS

 PR00153; CSAPPISMRASE.