CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040851
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myotubularin-related protein 1 
Protein Synonyms/Alias
  
Gene Name
 MTMR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84ENVSRDYKVFRRPDLubiquitination[1]
99RALRDGNKLAQMEEAubiquitination[1]
167GVISRVEKIGAQSHGubiquitination[1]
185CGIEIVCKDMRNLRLubiquitination[1]
195RNLRLAYKQEEQSKLubiquitination[1]
245YDPVSEYKRQGLPNEubiquitination[1]
255GLPNESWKISKINSNubiquitination[1]
258NESWKISKINSNYEFubiquitination[1]
286VKDDDLSKVAAFRAKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 673 AA 
Protein Sequence
MDRPAAAAAA GCEGGGGPNP GPAGGRRPPR AAGGATAGSR QPSVETLDSP TGSHVEWCKQ 60
LIAATISSQI SGSVTSENVS RDYKVFRRPD LRALRDGNKL AQMEEAPLFP GESIKAIVKD 120
VMYICPFMGA VSGTLTVTDF KLYFKNVERD PHFILDVPLG VISRVEKIGA QSHGDNSCGI 180
EIVCKDMRNL RLAYKQEEQS KLGIFENLNK HAFPLSNGQA LFAFSYKEKF PINGWKVYDP 240
VSEYKRQGLP NESWKISKIN SNYEFCDTYP AIIVVPTSVK DDDLSKVAAF RAKGRVPVLS 300
WIHPESQATI TRCSQPLVGP NDKRCKEDEK YLQTIMDANA QSHKLIIFDA RQNSVADTNK 360
TKGGGYESES AYPNAELVFL EIHNIHVMRE SLRKLKEIVY PSIDEARWLS NVDGTHWLEY 420
IRMLLAGAVR IADKIESGKT SVVVHCSDGW DRTAQLTSLA MLMLDSYYRT IKGFETLVEK 480
EWISFGHRFA LRVGHGNDNH ADADRSPIFL QFVDCVWQMT RQFPSAFEFN ELFLITILDH 540
LYSCLFGTFL CNCEQQRFKE DVYTKTISLW SYINSQLDEF SNPFFVNYEN HVLYPVASLS 600
HLELWVNYYV RWNPRMRPQM PIHQNLKELL AVRAELQKRV EGLQREVATR AVSSSSERGS 660
SPSHSATSVH TSV 673 
Gene Ontology
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR004182; GRAM.
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF02893; GRAM
 PF06602; Myotub-related 
SMART
 SM00568; GRAM 
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 
PRINTS