CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-2-HS-glycoprotein 
Protein Synonyms/Alias
 Countertrypin; Fetuin-A 
Gene Name
 Ahsg 
Gene Synonyms/Alias
 Fetua 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
65QVLNQIDKVKVWSRRubiquitination[1]
225KCNLLAEKQHGFCKAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Probably involved in differentiation. 
Sequence Annotation
 DOMAIN 19 133 Cystatin fetuin-A-type 1.
 DOMAIN 144 250 Cystatin fetuin-A-type 2.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 305 305 Phosphoserine.
 MOD_RES 309 309 Phosphoserine.
 MOD_RES 312 312 Phosphoserine.
 MOD_RES 314 314 Phosphoserine.
 CARBOHYD 99 99 N-linked (GlcNAc...).
 CARBOHYD 156 156 N-linked (GlcNAc...).
 CARBOHYD 176 176 N-linked (GlcNAc...).
 DISULFID 32 336 By similarity.
 DISULFID 89 100 By similarity.
 DISULFID 114 132 By similarity.
 DISULFID 146 149 By similarity.
 DISULFID 208 219 By similarity.
 DISULFID 230 247 By similarity.  
Keyword
 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 345 AA 
Protein Sequence
MKSLVLLLCF AQLWGCQSAP QGTGLGFREL ACDDPEAEQV ALLAVDYLNN HLLQGFKQVL 60
NQIDKVKVWS RRPFGVVYEM EVDTLETTCH ALDPTPLANC SVRQLTEHAV EGDCDFHILK 120
QDGQFRVMHT QCHSTPDSAE DVRKLCPRCP LLTPFNDTNV VHTVNTALAA FNTQNNGTYF 180
KLVEISRAQN VPLPVSTLVE FVIAATDCTA KEVTDPAKCN LLAEKQHGFC KANLMHNLGG 240
EEVSVACKLF QTQPQPANAN AVGPVPTANA ALPADPPASV VVGPVVVPRG LSDHRTYHDL 300
RHAFSPVASV ESASGETLHS PKVGQPGAAG PVSPMCPGRI RHFKI 345 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:InterPro.
 GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
 GO:0006953; P:acute-phase response; ISS:UniProtKB.
 GO:0030502; P:negative regulation of bone mineralization; IDA:UniProtKB.
 GO:0001503; P:ossification; IDA:MGI.
 GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB. 
Interpro
 IPR025760; Cystatin_Fetuin_A.
 IPR000010; Prot_inh_cystat.
 IPR001363; Prot_inh_fetuin_CS. 
Pfam
 PF00031; Cystatin 
SMART
 SM00043; CY 
PROSITE
 PS51529; CYSTATIN_FETUIN_A
 PS01254; FETUIN_1
 PS01255; FETUIN_2 
PRINTS