UniProt Accession

 Q8IIV2_PLAF7; Q8IIV2 

Genbank Protein ID

 AE014186 

Genbank Nucleotide ID

 AAN35650.1 

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

 PF11_0061 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Plasmodium falciparum (isolate 3D7) 

NCBI Taxa ID

 36329 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1, 2]
9	SGRGKGGKGLGKGGA	acetylation	[1, 2]
13	KGGKGLGKGGAKRHR	acetylation	[1, 2]
17	GLGKGGAKRHRKILR	acetylation	[1, 2]

Reference

 [1] Global histone analysis by mass spectrometry reveals a high content of acetylated lysine residues in the malaria parasite Plasmodium falciparum.
 Trelle MB, Salcedo-Amaya AM, Cohen AM, Stunnenberg HG, Jensen ON.
 J Proteome Res. 2009 Jul;8(7):3439-50. [PMID: 19351122]
 [2] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 

Sequence Annotation

  

Keyword

 Chromosome; Complete proteome; DNA-binding; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.