Tag | Content |
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CPLM ID | CPLM-004188 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CD59 glycoprotein |
Protein Synonyms/Alias | 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD59 |
Gene Name | CD59 |
Gene Synonyms/Alias | MIC11; MIN1; MIN2; MIN3; MSK21 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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66 | QVYNKCWKFEHCNFN | glycation | [1] |
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Reference | [1] Molecular basis for a link between complement and the vascular complications of diabetes. Acosta J, Hettinga J, Flückiger R, Krumrei N, Goldfine A, Angarita L, Halperin J. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5450-5. [ PMID: 10805801] |
Functional Description | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
Sequence Annotation | DOMAIN 26 108 UPAR/Ly6. LIPID 102 102 GPI-anchor amidated asparagine. CARBOHYD 43 43 N-linked (GlcNAc...). CARBOHYD 66 66 N-linked (Glc) (glycation). CARBOHYD 69 69 N-linked (Glc) (glycation). CARBOHYD 76 76 O-linked (GlcNAc...) (Probable). CARBOHYD 77 77 O-linked (GlcNAc...) (Probable). DISULFID 28 51 DISULFID 31 38 DISULFID 44 64 DISULFID 70 88 DISULFID 89 94 |
Keyword | 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycation; Glycoprotein; GPI-anchor; Hereditary hemolytic anemia; Lipoprotein; Membrane; Reference proteome; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 128 AA |
Protein Sequence | MGIQGGSVLF GLLLVLAVFC HSGHSLQCYN CPNPTADCKT AVNCSSDFDA CLITKAGLQV 60 YNKCWKFEHC NFNDVTTRLR ENELTYYCCK KDLCNFNEQL ENGGTSLSEK TVLLLVTPFL 120 AAAWSLHP 128 |
Gene Ontology | GO:0031362; C:anchored to external side of plasma membrane; IDA:MGI. GO:0043218; C:compact myelin; IEA:Compara. GO:0005615; C:extracellular space; IEA:Compara. GO:0042383; C:sarcolemma; IEA:Compara. GO:0007596; P:blood coagulation; TAS:ProtInc. GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc. GO:0001971; P:negative regulation of activation of membrane attack complex; IEA:Compara. GO:0043066; P:negative regulation of apoptotic process; IEA:Compara. GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara. |
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