CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044505
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein flightless-1 homolog 
Protein Synonyms/Alias
  
Gene Name
 FLII 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21DLSGNDFKGGYFPENacetylation[1]
21DLSGNDFKGGYFPENubiquitination[1, 2, 3, 4, 5]
30GYFPENVKAMTSLRWubiquitination[3, 5]
92VARANSLKNSGVPDDubiquitination[2, 3, 5]
290SLPSAICKLSKLKKLubiquitination[4]
293SAICKLSKLKKLYLNubiquitination[4]
303KLYLNSNKLDFDGLPubiquitination[2, 3, 4, 5]
446DQAKQVLKGMSDVAQubiquitination[2, 4]
458VAQEKNKKQEESADAubiquitination[4]
481RWDQGLEKPRLDYSEubiquitination[2, 4]
630VYGKKNIKLEPVPLKacetylation[6]
637KLEPVPLKGTSLDPRubiquitination[4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH 60
LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP 120
RELENAKNML VLNLSHNSID TIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV 180
LNGNPLLHAQ LRQLPAMTAL QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE 240
CLYTLPSLRR LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN 300
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN HLVTLPEAIH 360
FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL RLAGASPATV AAAAAGSGPK 420
DPMARKMRLR RRKDSAQDDQ AKQVLKGMSD VAQEKNKKQE ESADARAPSG KVRRWDQGLE 480
KPRLDYSEFF TEDVGQLPGL TIWQIENFVP VLVEEAFHGK FYEADCYIVL KTFLDDSGSL 540
NWEIYYWIGG EATLDKKACS AIHAVNLRNY LGAECRTVRE EMGDESEEFL QVFDNDISYI 600
EGGTASGFYT VEDTHYVTRM YRVYGKKNIK LEPVPLKGTS LDPRNMSGRA GCAWSARAMS 660
STPLPAASTP GAPSARPWPK TGWHSPRLGE EEEGASSTVC 700 
Gene Ontology
  
Interpro
 IPR007123; Gelsolin_dom.
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR007122; Villin/Gelsolin. 
Pfam
 PF00626; Gelsolin
 PF00560; LRR_1
 PF12799; LRR_4 
SMART
 SM00262; GEL
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS
 PR00597; GELSOLIN.