| Tag | Content |
|---|
| CPLM ID | CPLM-018580 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neurolysin, mitochondrial |
Protein Synonyms/Alias | Microsomal endopeptidase; MEP; Mitochondrial oligopeptidase M; Neurotensin endopeptidase |
Gene Name | Nln |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 253 | PHYFPVMKKCCVPET | acetylation | [1] | | 263 | CVPETRRKMEMAFHT | acetylation | [1] | | 583 | LRQIVLSKVDQSLHT | acetylation | [1] | | 693 | LQREPNQKAFLMSRG | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). |
Sequence Annotation | ACT_SITE 498 498 By similarity.
METAL 497 497 Zinc; catalytic (By similarity).
METAL 501 501 Zinc; catalytic (By similarity).
METAL 504 504 Zinc; catalytic (By similarity).
MOD_RES 664 664 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Protease; Reference proteome; Transit peptide; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 704 AA |
Protein Sequence | MITLCLSALR GLHRAGGSRI RLRMTLGREA ASPLQAMSSY TAAGRNVLRW DLSPEQIRTR 60
TEELIAQTKQ VYDTVGTINL EDVTYENCLQ VLADIEVKYI VERTMLDFPQ HVSSDREVRA 120
ASTEADKRLS RFDIEMSMRE DVFQRIVHLQ ETCDLEKIKP EARRYLEKSI KMGKRNGLHL 180
PEHVKNEIKS MKKRMSELCI DFNKNLNEDD TSLVFSKAEL GALPDDFIDS LEKTDEDKYK 240
VTLKYPHYFP VMKKCCVPET RRKMEMAFHT RCKEENTIIL QQLLPLRAQV AKLLGYNTHA 300
DFVLELNTAK STSHVATFLD DLSQKLKPLG EAEREFILSL KKKECEERGF AYDGKINAWD 360
LHYYMTQTEE LKYSVDQESL KEYFPIEVVT EGLLSIYQEL LGLSFEQVAD AHVWNKSVSL 420
YTVKDKATGE VLGQFYLDLY PREGKYNHAA CFGLQPGCLL PDGSRMMSVA ALVVNFSQPI 480
AGRPSLLRHD EVRTYFHEFG HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDID 540
SLRKLSKHYR DGHPITDELL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NASLDAASEY 600
AKYCTEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFHSC FRKEGIMNPE 660
VGMKYRNLIL KPGGSLDGMD MLQNFLQREP NQKAFLMSRG LNAS 704 |
Gene Ontology | GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:MGI. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |