UniProt Accession

 PP2A1_YEAST; P23594; D6VRL4 

Genbank Protein ID

 X56261; X58856; X96876; Z74182; BK006938 

Genbank Nucleotide ID

 CAA39702.1; CAA41656.1; CAA65625.1; CAA98707.1; DAA11724.1 

Protein Name

 Serine/threonine-protein phosphatase PP2A-1 catalytic subunit 

Protein Synonyms/Alias

  

Gene Name

 PPH21 

Gene Synonyms/Alias

 YDL134C; D2180 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
363	GEPSVSRKTPDYFL*	ubiquitination	[1, 2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Exact function not known, phosphatase 2A performs an essential cellular function. 

Sequence Annotation

 ACT_SITE 178 178 Proton donor (By similarity).
 METAL 117 117 Iron (By similarity).
 METAL 119 119 Iron (By similarity).
 METAL 145 145 Iron (By similarity).
 METAL 145 145 Manganese (By similarity).
 METAL 177 177 Manganese (By similarity).
 METAL 227 227 Manganese (By similarity).
 METAL 301 301 Manganese (By similarity).
 MOD_RES 369 369 Leucine methyl ester; affects formation  

Keyword

 Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Methylation; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000159; C:protein phosphatase type 2A complex; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004722; F:protein serine/threonine phosphatase activity; IMP:SGD.
 GO:0007015; P:actin filament organization; TAS:SGD.
 GO:0007117; P:budding cell bud growth; TAS:SGD.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IGI:SGD.
 GO:0007094; P:mitotic spindle assembly checkpoint; IPI:SGD.
 GO:0006470; P:protein dephosphorylation; TAS:SGD.
 GO:0006417; P:regulation of translation; IPI:SGD. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.