CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037660
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Poly [ADP-ribose] polymerase 10 
Protein Synonyms/Alias
  
Gene Name
 PARP10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
907RNATVYGKGVYFARRacetylation[1]
907RNATVYGKGVYFARRubiquitination[2, 3, 4, 5]
932PPNADGHKAVFVARVubiquitination[4, 5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1016 AA 
Protein Sequence
MVAMAEAEAG VAVEVRGLPP AVPDELLTLY FENRRRSGGG PVLSWQRLGC GGVLTFREPA 60
DAERVLAQAD HELHGAQLSL RPAPPRAPAR LLLQGLPPGT TPQRLEQHVQ ALLRASGLPV 120
QPCCALASPR PDRALVQLPK PLSEADVRVL EEQAQNLGLE GTLVSLARVP QARAVRVVGD 180
GASVDLLLLE LYLENERRSG GGPLEDLQRL PGPLGTVASF QQWQVAERVL QQEHRLQGSE 240
LSLVPHYDIL EPEELAENTS GGDHPSTQGP RATKHALLRT GGLVTALQGA GTVTMGSGEE 300
PGQSGASLRT GPMVQGRGIM TTGSGQEPGQ SGTSLRTGPM GSLGQAEQVS SMPMGSLEHE 360
GLVSLRPVGL QEQEGPMSLG PVGSAGPVET SKGLLGQEGL VEIAMDSPEQ EGLVGPMEIT 420
MGSLEKAGPV SPGCVKLAGQ EGLVEMVLLM EPGAMRFLQL YHEDLLAGLG DVALLPLEGP 480
DMTGFRLCGA QASCQAAEEF LRSLLGSISC HVLCLEHPGS ARFLLGPEGQ HLLQGLEAQF 540
QCVFGTERLA TATLDTGLEE VDPTEALPVL PGNAHTLWTP DSTEEVRELL ATLEGLDLDG 600
EDWLPRELEE EGPQEQPEEE VTPGHEEEEP VAPSTVAPRW LEEEAALQLA LHRSLEPQGQ 660
VAEQEEAAAL RQALTLSLLE QPPLEAEEPP DGGTDGKAQL VVHSAFEQDV EELDRALRAA 720
LEVHVQEETV GPWRRTLPAE LRARLERCHG VSVALRGDCT ILRGFGAHPA RAARHLVALL 780
AGPWDQSLAF PLAASGPTLA GQTLKGPWNN LERLAENTGE FQEVVRAFYD TLDAARSSIR 840
VVRVERVSHP LLQQQYELYR ERLLQRCERR PVEQVLYHGT TAPAVPDICA HGFNRSFCGR 900
NATVYGKGVY FARRASLSVQ DRYSPPNADG HKAVFVARVL TGDYGQGRRG LRAPPLRGPG 960
HVLLRYDSAV DCICQPSIFV IFHDTQALPT HLITCEHVPR ASPDDPSGLP GRSPDT 1016 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro. 
Interpro
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR003903; Ubiquitin-int_motif. 
Pfam
 PF00644; PARP 
SMART
 SM00726; UIM 
PROSITE
 PS51059; PARP_CATALYTIC 
PRINTS