| Tag | Content |
|---|
| CPLM ID | CPLM-002035 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA helicase II |
Protein Synonyms/Alias | |
Gene Name | uvrD |
Gene Synonyms/Alias | mutU; pdeB; rad; recL; b3813; JW3786 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 448 | CRELLQEKALAGRAA | acetylation | [1] | | 623 | ETRRLYGKEVYHRPS | acetylation | [1] | | 680 | GQRVRHAKFGEGTIV | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. |
Sequence Annotation | DOMAIN 8 286 UvrD-like helicase ATP-binding.
DOMAIN 287 564 UvrD-like helicase C-terminal.
NP_BIND 32 37 ATP (By similarity).
BINDING 284 284 ATP (By similarity). |
Keyword | 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome; SOS response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 720 AA |
Protein Sequence | MDVSYLLDSL NDKQREAVAA PRSNLLVLAG AGSGKTRVLV HRIAWLMSVE NCSPYSIMAV 60
TFTNKAAAEM RHRIGQLMGT SQGGMWVGTF HGLAHRLLRA HHMDANLPQD FQILDSEDQL 120
RLLKRLIKAM NLDEKQWPPR QAMWYINSQK DEGLRPHHIQ SYGNPVEQTW QKVYQAYQEA 180
CDRAGLVDFA ELLLRAHELW LNKPHILQHY RERFTNILVD EFQDTNNIQY AWIRLLAGDT 240
GKVMIVGDDD QSIYGWRGAQ VENIQRFLND FPGAETIRLE QNYRSTSNIL SAANALIENN 300
NGRLGKKLWT DGADGEPISL YCAFNELDEA RFVVNRIKTW QDNGGALAEC AILYRSNAQS 360
RVLEEALLQA SMPYRIYGGM RFFERQEIKD ALSYLRLIAN RNDDAAFERV VNTPTRGIGD 420
RTLDVVRQTS RDRQLTLWQA CRELLQEKAL AGRAASALQR FMELIDALAQ ETADMPLHVQ 480
TDRVIKDSGL RTMYEQEKGE KGQTRIENLE ELVTATRQFS YNEEDEDLMP LQAFLSHAAL 540
EAGEGQADTW QDAVQLMTLH SAKGLEFPQV FIVGMEEGMF PSQMSLDEGG RLEEERRLAY 600
VGVTRAMQKL TLTYAETRRL YGKEVYHRPS RFIGELPEEC VEEVRLRATV SRPVSHQRMG 660
TPMVENDSGY KLGQRVRHAK FGEGTIVNME GSGEHSRLQV AFQGQGIKWL VAAYARLESV 720 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0006281; P:DNA repair; IEA:UniProtKB-KW. GO:0006268; P:DNA unwinding involved in replication; IEA:InterPro. GO:0009432; P:SOS response; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |