| Tag | Content |
|---|
| CPLM ID | CPLM-023420 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WD repeat-containing protein mio |
Protein Synonyms/Alias | Missing oocyte protein |
Gene Name | mio |
Gene Synonyms/Alias | CG7074 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 176 | GMSQKMIKLFDLRQS | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Involved in the differentiation of the oocyte nucleus. Influences meiotic progression prior to pachytene and possibly by interacting with pathways that control DNA metabolism. May act in the oocyte nucleus to facilitate the execution of the unique cell cycle and developmental programs that produce the mature haploid gamete. |
Sequence Annotation | REPEAT 51 86 WD 1.
REPEAT 100 144 WD 2.
REPEAT 149 188 WD 3.
REPEAT 190 228 WD 4.
REPEAT 231 272 WD 5. |
Keyword | Complete proteome; Developmental protein; Differentiation; Nucleus; Oogenesis; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 867 AA |
Protein Sequence | MSGNTHGLSW FPHFPDKFVS WGQEIHLYEV RRKDDHSQKS RLPYISVNYL ANESRYQYAR 60
CVAASYHSDQ PIIAVGLADG KVGICNFRDT YDSSWEYTPR QQRMCTCLAW NELDANILAI 120
GHDRHRNDTC ITIWDIERGV PKETANFFGV GESANSICWD RNHRTVIAGM SQKMIKLFDL 180
RQSNATCQSI QTKTVQGLSV SPNGNYLCSY VDSVITLWDP RNIKSPLRQI QSSKNHLQIA 240
WCPTRTSLLS SLQRDSSYIT LYDIRSVDTD NSGEIYHVKR QISPFPARYQ HSGKFSFVNC 300
LSWHSRDFER ALLLADALNI LDFRLPATLH TAHSNRRKLP LLMQRPLYTP ASPTSTAATP 360
TQQQPTSSCS TNSGSSLDFS TPGGSPFNVD LLKPELFELD LVDETRQRAL EDYGIKPDNK 420
RFGELHLTPY LRNVWSTLNN VYSEDRLTGL KATLGINLGH TSEALMASSR IESQVLQWPE 480
GINNSNKLIC YRSEQRDLAL QLCGWAFEQE LDRFIDQLYA NKEYSRAAMI CVFHLKIFHA 540
CNILSSAADN MRDPSMYRIT VIALSSFNAD RCSSTWRNQR SSANMQIHDP HLRAVFSFLT 600
MEKDNFDAVL KEEGVSLSDR MAFACKYLSE TKLADYVAQQ IQAAIDGGDL NGLLLTGESQ 660
DGIDILQSYM DTSFDVQTVA LVAINYFRQE LFEDKRIQYW IASYLDHLNS WGLWEKRAEL 720
DIKIESIRPS SRSSRTVFLS CNFCGKSVSN ALLDEPRPRS TTTSTNRLSS CPSCRKPLPR 780
CSLCLMHMGT MVNMSNGETP TTTPDVPGWQ TKPFSKWFSW CQTCRHGGHT EHIMQWFKQN 840
SECPVSSCNC RCFDMDGTKP NTLRDIS 867 |
Gene Ontology | GO:0001674; C:female germ cell nucleus; IDA:UniProtKB. GO:0043234; C:protein complex; IPI:FlyBase. GO:0006302; P:double-strand break repair; IMP:FlyBase. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0009994; P:oocyte differentiation; IMP:UniProtKB. GO:0030716; P:oocyte fate determination; IMP:FlyBase. GO:0040020; P:regulation of meiosis; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |