CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004309
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myoblast determination protein 1 
Protein Synonyms/Alias
 Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3 
Gene Name
 MYOD1 
Gene Synonyms/Alias
 BHLHC1; MYF3; MYOD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99RCLLWACKACKRKTTacetylation[1]
102LWACKACKRKTTNADacetylation[1]
104ACKACKRKTTNADRRacetylation[1]
Reference
 [1] Proteome-wide prediction of acetylation substrates.
 Basu A, Rose KL, Zhang J, Beavis RC, Ueberheide B, Garcia BA, Chait B, Zhao Y, Hunt DF, Segal E, Allis CD, Hake SB.
 Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13785-90. [PMID: 19666589] 
Functional Description
 Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). 
Sequence Annotation
 DOMAIN 109 160 bHLH.
 CROSSLNK 1 1 Peptide (Met-Gly) (interchain with G-Cter  
Keyword
 Acetylation; Complete proteome; Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 320 AA 
Protein Sequence
MELLSPPLRD VDLTAPDGSL CSFATTDDFY DDPCFDSPDL RFFEDLDPRL MHVGALLKPE 60
EHSHFPAAVH PAPGAREDEH VRAPSGHHQA GRCLLWACKA CKRKTTNADR RKAATMRERR 120
RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL RNAIRYIEGL QALLRDQDAA PPGAAAAFYA 180
PGPLPPGRGG EHYSGDSDAS SPRSNCSDGM MDYSGPPSGA RRRNCYEGAY YNEAPSEPRP 240
GKSAAVSSLD CLSSIVERIS TESPAAPALL LADVPSESPP RRQEAAAPSE GESSGDPTQS 300
PDAAPQCPAG ANPNPIYQVL 320 
Gene Ontology
 GO:0030016; C:myofibril; IEA:Compara.
 GO:0000790; C:nuclear chromatin; ISS:BHF-UCL.
 GO:0005667; C:transcription factor complex; ISS:BHF-UCL.
 GO:0070888; F:E-box binding; ISS:BHF-UCL.
 GO:0046982; F:protein heterodimerization activity; ISS:BHF-UCL.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Compara.
 GO:0071453; P:cellular response to oxygen levels; IEA:Compara.
 GO:0009267; P:cellular response to starvation; IEA:Compara.
 GO:0042693; P:muscle cell fate commitment; ISS:BHF-UCL.
 GO:0007518; P:myoblast fate determination; IEA:Compara.
 GO:0014904; P:myotube cell development; IDA:BHF-UCL.
 GO:0014908; P:myotube differentiation involved in skeletal muscle regeneration; IEA:Compara.
 GO:0051149; P:positive regulation of muscle cell differentiation; IDA:BHF-UCL.
 GO:1901741; P:positive regulation of myoblast fusion; IDA:BHF-UCL.
 GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0006468; P:protein phosphorylation; TAS:ProtInc.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Compara.
 GO:0043484; P:regulation of RNA splicing; IDA:BHF-UCL.
 GO:0043503; P:skeletal muscle fiber adaptation; IEA:Compara.
 GO:0048741; P:skeletal muscle fiber development; IEA:Compara. 
Interpro
 IPR002546; Basic.
 IPR011598; bHLH_dom.
 IPR022032; Myf5. 
Pfam
 PF01586; Basic
 PF00010; HLH
 PF12232; Myf5 
SMART
 SM00520; BASIC
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS